Rescue of a Cytopathic Paramyxovirus From Peripheral Blood Leukocytes in Subacute Sclerosing Panencephalitis

Steven J. Robbins, Helena Wrzos, Anita L. Kline, Richard Tenser, Fred Rapp

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

An infectious, cytopathic paramyxovirus was rescued from the peripheral blood leukocytes of a patient with subacute sclerosing panencephalitis (SSPE) by cocultivation procedures. Cells infected with the virus (1) demonstrated polykaryocytosis, (2) contained cytoplasmic inclusion bodies of paramyxoviral nucleocapsids, (3) hemadsorbed monkey erythrocytes, and (4) reacted with fluorescein-conjugated antisera to measles virus. On the basis of these observations, the virus was initially believed to be a measles-like virus similar to those that have been rescued from other patients with SSPE. However, subsequent immunologic and molecular studies showed that the virus was distinct from measles virus and was more closely related to simian virus 5. These findings suggest that paramyxoviruses other than measles virus can be nonproductively carried by patients with SSPE and should not be designated as “measles like” or “measles related” solely on the basis of their biologic characteristics.

Original languageEnglish (US)
Pages (from-to)396-403
Number of pages8
JournalJournal of Infectious Diseases
Volume143
Issue number3
DOIs
StatePublished - Jan 1 1981

Fingerprint

Subacute Sclerosing Panencephalitis
Measles virus
Leukocytes
Inclusion Bodies
Measles
Viruses
Parainfluenza Virus 5
Nucleocapsid
Coculture Techniques
Fluorescein
Haplorhini
Immune Sera
Erythrocytes

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Robbins, Steven J. ; Wrzos, Helena ; Kline, Anita L. ; Tenser, Richard ; Rapp, Fred. / Rescue of a Cytopathic Paramyxovirus From Peripheral Blood Leukocytes in Subacute Sclerosing Panencephalitis. In: Journal of Infectious Diseases. 1981 ; Vol. 143, No. 3. pp. 396-403.
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Rescue of a Cytopathic Paramyxovirus From Peripheral Blood Leukocytes in Subacute Sclerosing Panencephalitis. / Robbins, Steven J.; Wrzos, Helena; Kline, Anita L.; Tenser, Richard; Rapp, Fred.

In: Journal of Infectious Diseases, Vol. 143, No. 3, 01.01.1981, p. 396-403.

Research output: Contribution to journalArticle

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