Residual Minor Histocompatibility Genes Contaminate the B10. AM Congenic Line: No Evidence of C‐Region‐Controlled Histoincompatibility

A. JURETIĆ, N. PROTRKA, P. WALDEN, Z. A. NAGY, J. KLEIN

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Abstract

After being primed in vivo and restimulated in vitro, cytolytic T lymphocytes (CTL) were produced in the strain combinations B10.AM ami‐B10.A(1R) and B10.A(1R) anti‐B10.AM. Although the two strains differ in the chromosomal interval between the Eα and the D loci, the CTL are not directed against antigens controlled by loci in this interval. Instead, the CTL detect minor histocompatibility (H) antigens controlled by loci that are notlinked to H‐2. The recognition of the antigens detected by the B10. AM anti‐B10.A(lR) CTL is restricted by the Kk and Db molecules, but the CTL also cross‐react with the Dd molecule (or a molecule controlled by a locus closely linked to Dd). The recognition of the antigens detected by these two CTL behave as if controlled by alleles at the same minor H locus or loci. This locus is distinct from H‐2, and the B 10. AM congenic line apparently retained a C3H‐derived allele at this locus.

Original languageEnglish (US)
Pages (from-to)515-519
Number of pages5
JournalScandinavian Journal of Immunology
Volume18
Issue number6
DOIs
StatePublished - Dec 1983

All Science Journal Classification (ASJC) codes

  • Immunology

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