Abstract
Bacteria have the remarkable ability to communicate as a group in what has become known as quorum sensing (QS), and this trait has been associated with important bacterial phenotypes, such as virulence and biofilm formation. Bacteria also have an incredible ability to evolve resistance to all known antimicrobials. Hence, although inhibition of QS has been hailed as a means to reduce virulence in a manner that is impervious to bacterial resistance mechanisms, this approach is unlikely to be a panacea. Here we review the evidence that bacteria can evolve resistance to quorum-quenching compounds.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6840-6846 |
| Number of pages | 7 |
| Journal | Applied and environmental microbiology |
| Volume | 79 |
| Issue number | 22 |
| DOIs | |
| State | Published - Nov 1 2013 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Food Science
- Applied Microbiology and Biotechnology
- Ecology
Cite this
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Resistance to quorum-quenching compounds. / García-Contreras, Rodolfo; Maeda, Toshinari; Wood, Thomas K.
In: Applied and environmental microbiology, Vol. 79, No. 22, 01.11.2013, p. 6840-6846.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Resistance to quorum-quenching compounds
AU - García-Contreras, Rodolfo
AU - Maeda, Toshinari
AU - Wood, Thomas K.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Bacteria have the remarkable ability to communicate as a group in what has become known as quorum sensing (QS), and this trait has been associated with important bacterial phenotypes, such as virulence and biofilm formation. Bacteria also have an incredible ability to evolve resistance to all known antimicrobials. Hence, although inhibition of QS has been hailed as a means to reduce virulence in a manner that is impervious to bacterial resistance mechanisms, this approach is unlikely to be a panacea. Here we review the evidence that bacteria can evolve resistance to quorum-quenching compounds.
AB - Bacteria have the remarkable ability to communicate as a group in what has become known as quorum sensing (QS), and this trait has been associated with important bacterial phenotypes, such as virulence and biofilm formation. Bacteria also have an incredible ability to evolve resistance to all known antimicrobials. Hence, although inhibition of QS has been hailed as a means to reduce virulence in a manner that is impervious to bacterial resistance mechanisms, this approach is unlikely to be a panacea. Here we review the evidence that bacteria can evolve resistance to quorum-quenching compounds.
UR - http://www.scopus.com/inward/record.url?scp=84886699628&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886699628&partnerID=8YFLogxK
U2 - 10.1128/AEM.02378-13
DO - 10.1128/AEM.02378-13
M3 - Review article
C2 - 24014536
AN - SCOPUS:84886699628
VL - 79
SP - 6840
EP - 6846
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
SN - 0099-2240
IS - 22
ER -