Resistance to quorum-quenching compounds

Rodolfo García-Contreras; Toshinari Maeda; Thomas K. Wood

doi:10.1128/AEM.02378-13

Resistance to quorum-quenching compounds

Rodolfo García-Contreras, Toshinari Maeda, Thomas K. Wood

Research output: Contribution to journal › Review article › peer-review

78 Scopus citations

Abstract

Bacteria have the remarkable ability to communicate as a group in what has become known as quorum sensing (QS), and this trait has been associated with important bacterial phenotypes, such as virulence and biofilm formation. Bacteria also have an incredible ability to evolve resistance to all known antimicrobials. Hence, although inhibition of QS has been hailed as a means to reduce virulence in a manner that is impervious to bacterial resistance mechanisms, this approach is unlikely to be a panacea. Here we review the evidence that bacteria can evolve resistance to quorum-quenching compounds.

Original language	English (US)
Pages (from-to)	6840-6846
Number of pages	7
Journal	Applied and environmental microbiology
Volume	79
Issue number	22
DOIs	https://doi.org/10.1128/AEM.02378-13
State	Published - Nov 2013

All Science Journal Classification (ASJC) codes

Biotechnology
Food Science
Applied Microbiology and Biotechnology
Ecology

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abstract = "Bacteria have the remarkable ability to communicate as a group in what has become known as quorum sensing (QS), and this trait has been associated with important bacterial phenotypes, such as virulence and biofilm formation. Bacteria also have an incredible ability to evolve resistance to all known antimicrobials. Hence, although inhibition of QS has been hailed as a means to reduce virulence in a manner that is impervious to bacterial resistance mechanisms, this approach is unlikely to be a panacea. Here we review the evidence that bacteria can evolve resistance to quorum-quenching compounds.",

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AU - Wood, Thomas K.

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AB - Bacteria have the remarkable ability to communicate as a group in what has become known as quorum sensing (QS), and this trait has been associated with important bacterial phenotypes, such as virulence and biofilm formation. Bacteria also have an incredible ability to evolve resistance to all known antimicrobials. Hence, although inhibition of QS has been hailed as a means to reduce virulence in a manner that is impervious to bacterial resistance mechanisms, this approach is unlikely to be a panacea. Here we review the evidence that bacteria can evolve resistance to quorum-quenching compounds.

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Resistance to quorum-quenching compounds

Abstract

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