Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

Cara Lynne Schengrund, Mary Ann Repman, Beth A. Sheffler

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Injection (s.c.) of 2 × 105 S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.

Original languageEnglish (US)
Pages (from-to)229-235
Number of pages7
JournalCancer Letters
Volume17
Issue number2
DOIs
StatePublished - Jan 1 1982

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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