Injection (s.c.) of 2 × 105 S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.
All Science Journal Classification (ASJC) codes
- Cancer Research