Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

Cara Lynne Schengrund; Mary Ann Repman; Beth A. Sheffler

doi:10.1016/0304-3835(82)90037-4

Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

Cara Lynne Schengrund, Mary Ann Repman, Beth A. Sheffler

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Injection (s.c.) of 2 × 10⁵ S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.

Original language	English (US)
Pages (from-to)	229-235
Number of pages	7
Journal	Cancer Letters
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(82)90037-4
State	Published - 1982

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/0304-3835(82)90037-4

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title = "Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates",

abstract = "Injection (s.c.) of 2 × 105 S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.",

author = "Schengrund, {Cara Lynne} and Repman, {Mary Ann} and Sheffler, {Beth A.}",

note = "Funding Information: We thank Dr. G. Barlett for helpful discussions. Supported by grants CA14319 and CA18450 awarded by the National Cancer Institute.",

year = "1982",

doi = "10.1016/0304-3835(82)90037-4",

language = "English (US)",

volume = "17",

pages = "229--235",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

AU - Schengrund, Cara Lynne

AU - Repman, Mary Ann

AU - Sheffler, Beth A.

N1 - Funding Information: We thank Dr. G. Barlett for helpful discussions. Supported by grants CA14319 and CA18450 awarded by the National Cancer Institute.

PY - 1982

Y1 - 1982

N2 - Injection (s.c.) of 2 × 105 S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.

AB - Injection (s.c.) of 2 × 105 S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.

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SN - 0304-3835

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JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

Abstract

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