Response of testosterone and cortisol concentrations to high-intensity resistance exercise following creatine supplementation

Jeff S. Volek, Mark Boetes, Jill A. Bush, Margot Putukian, Wayne J. Sebastianelli, William J. Kraemer

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


This study investigated the influence of oral creatine monohydrate supplementation on hormone responses to high-intensity resistance exercise in 13 healthy, normally active men. Subjects were randomly assigned in double-blind fashion to either a creatine or placebo group. Both groups performed bench press and jump squat exercise protocols before (T1) and after (T2) ingesting either 25 g creatine monohydrate or placebo per day for 7 days. Blood samples were obtained pre- and 5 min postexercise to determine serum lactate, testosterone, and cortisol concentrations. Creatine ingestion resulted in a significant (p ≤ 0.05) increase in body mass but no changes in skinfold thickness. Serum lactate concentrations were significantly higher at 5 min postexercise in both groups compared to resting values. From T1 to T2 there were no significant differences in postexercise lactate concentration during both exercise protocols in the placebo group, but the creatine group had significantly higher lactate concentrations after the bench press and a trend toward lower concentrations during the jump squat at T2. There were significant increases in testosterone concentration postexercise after the jump squat, but not the bench press, for both groups; 5-min postexercise cortisol concentrations did not differ significantly from preexercise values for both groups for either protocol. Creatine supplementation may increase body mass; however, testosterone and cortisol may not mediate this initial effect.

Original languageEnglish (US)
Pages (from-to)182-187
Number of pages6
JournalJournal of Strength and Conditioning Research
Issue number3
StatePublished - Jan 1 1997

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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