Response of the Prepubertal Ovary to Acute Chorionic Gonadotropin Administration: Absence of Modulation by Growth Hormone

H. E. Kulin, E. Samojlik, L. M. Demers, S. J. Santner

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Twenty-five short term hCG stimulation tests were performed in seven prepubertal girls, aged 3-11 yr, who were being evaluated for short stature. Provocative testing revealed GH deficiency in all patients, but reevaluation of one girl at a later date showed normal somatotropin levels. The study protocol lasted 18 months and included testing before, during, and after 1 yr of GH therapy. Δ4-Androstenedione, testosterone, estrone, and estradiol were determined 0, 24, 48, and 72 h after initiation of a two-injection course of CG. Significant responses (∼ 2-fold over baseline) to the stimulation tests occurred for all steroids except testosterone, though no augmented effects were found in the presence of human GH. The results indicate functional capability of the prepubertal ovary when exposed acutely to a LH-like material, but no role for somatotropin in gonadal steroid production in the prepubertal female.

Original languageEnglish (US)
Pages (from-to)208-211
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume60
Issue number1
DOIs
StatePublished - Jan 1985

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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