Responses of anterior hypothalamic neurons to stimulation of aortic nerve and caudate nucleus in rabbits

Andrew L. Brickman; Marc P. Kaufman; Guy K. Petrik; Neil Schneiderman

doi:10.1016/0014-4886(77)90325-9

Responses of anterior hypothalamic neurons to stimulation of aortic nerve and caudate nucleus in rabbits

Andrew L. Brickman, Marc P. Kaufman, Guy K. Petrik, Neil Schneiderman

Research output: Contribution to journal › Article › peer-review

Original language	English (US)
Pages (from-to)	622-627
Number of pages	6
Journal	Experimental Neurology
Volume	56
Issue number	3
DOIs	https://doi.org/10.1016/0014-4886(77)90325-9
State	Published - Sep 1977

All Science Journal Classification (ASJC) codes

Neurology
Developmental Neuroscience

Access to Document

10.1016/0014-4886(77)90325-9

Cite this

@article{d977fbef2a7e4a4c871df4ddfa8bbf81,

title = "Responses of anterior hypothalamic neurons to stimulation of aortic nerve and caudate nucleus in rabbits",

author = "Brickman, {Andrew L.} and Kaufman, {Marc P.} and Petrik, {Guy K.} and Neil Schneiderman",

note = "Funding Information: An increase of pressure within the cat{\textquoteright}s carotid sinus influences the clis-charge rate of some anterior hypothalamic neurons (8). This suggests that these neurons receive barosensory input. Using electrical stimulation of rabbit aortic nerve to provide barosensory stimulation, we have extended the investigation of barosensory input to anterior hypothalamic neurons by more closely analyzing unit response latencies and topographies based on multiple stimulus presentations. The rabbit aortic nerve was chosen because studies of electrical stimulation of the cat carotid sinus nerve are hampered by problems of current spread (9) and the effects of concomitant stimulation of the baroreceptors and chemoreceptors (2). In contrast, the aortic nerve in the rabbit conveys only barosensory information ( 1). Electrical stimulation of the anterior hypothalamus in the rabbit (3) or cat (5) produces depressor responses and bradycardia that can be augmented by baroreceptor stimulation. Anatomic connections between the caudate nucleus and the hypothalamus have previously been documented (10). This raises the possibility that neurons in the anterior hypothalamus mediating cardiovascular changes may be influenced by the caudate nucleus. We therefore attempted to demonstrate electrophysiologically that neurons in anterior hypothalamus receiving barosensory input can also receive input from the caudate nucleus. Each of 56 female albino rabbits was anesthetized intravenously with sodium pentobarbital (25 to 35 “g/kg). Heart rate was recorded on-line 1 This study was supported by National Science Foundation research Grant BMS 75-10967. The present address of Andrew L. Brickman is Department of Physiology, University of Western Ontario, London, Ontario, Canada N6A SCI.",

year = "1977",

month = sep,

doi = "10.1016/0014-4886(77)90325-9",

language = "English (US)",

volume = "56",

pages = "622--627",

journal = "Neurodegeneration",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - Responses of anterior hypothalamic neurons to stimulation of aortic nerve and caudate nucleus in rabbits

AU - Brickman, Andrew L.

AU - Kaufman, Marc P.

AU - Petrik, Guy K.

AU - Schneiderman, Neil

N1 - Funding Information: An increase of pressure within the cat’s carotid sinus influences the clis-charge rate of some anterior hypothalamic neurons (8). This suggests that these neurons receive barosensory input. Using electrical stimulation of rabbit aortic nerve to provide barosensory stimulation, we have extended the investigation of barosensory input to anterior hypothalamic neurons by more closely analyzing unit response latencies and topographies based on multiple stimulus presentations. The rabbit aortic nerve was chosen because studies of electrical stimulation of the cat carotid sinus nerve are hampered by problems of current spread (9) and the effects of concomitant stimulation of the baroreceptors and chemoreceptors (2). In contrast, the aortic nerve in the rabbit conveys only barosensory information ( 1). Electrical stimulation of the anterior hypothalamus in the rabbit (3) or cat (5) produces depressor responses and bradycardia that can be augmented by baroreceptor stimulation. Anatomic connections between the caudate nucleus and the hypothalamus have previously been documented (10). This raises the possibility that neurons in the anterior hypothalamus mediating cardiovascular changes may be influenced by the caudate nucleus. We therefore attempted to demonstrate electrophysiologically that neurons in anterior hypothalamus receiving barosensory input can also receive input from the caudate nucleus. Each of 56 female albino rabbits was anesthetized intravenously with sodium pentobarbital (25 to 35 “g/kg). Heart rate was recorded on-line 1 This study was supported by National Science Foundation research Grant BMS 75-10967. The present address of Andrew L. Brickman is Department of Physiology, University of Western Ontario, London, Ontario, Canada N6A SCI.

PY - 1977/9

Y1 - 1977/9

UR - http://www.scopus.com/inward/record.url?scp=0017650384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017650384&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(77)90325-9

DO - 10.1016/0014-4886(77)90325-9

M3 - Article

C2 - 885206

AN - SCOPUS:0017650384

SN - 0014-4886

VL - 56

SP - 622

EP - 627

JO - Neurodegeneration

JF - Neurodegeneration

IS - 3

ER -

Responses of anterior hypothalamic neurons to stimulation of aortic nerve and caudate nucleus in rabbits

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Cite this