Experimentally induced diabetes in the rat resulted in an increased level of alpha-glycosidases in the intestine but a depression in their levels in the kidney. Rat intestine exhibited a differential stimulation of maltase, sucrase and trehalase activities. The variations depended on the duration of diabetes and the β-cytotoxic compounds used i.e. alloxan and streptozotocin. The maximum elevation in terms of total units and specific activity was observed on the 30th day in the following order: maltase > sucrase > trehalase. A significant observation emerging from this study is that the level of intestinal enzymes increases while that of the kidney enzymes declined during the period. Although intestinal and renal alpha-glycosidases are known to be structurally and biochemically similar, their opposing responses to diabetes indicates that they are under different regulatory mechanisms in these tissues.
All Science Journal Classification (ASJC) codes
- Molecular Biology