Responses of intestinal and renal alpha-glycosidases to alloxan and streptozotocin-induced diabetes: A comparative study

Suresh D. Sharma, S. Sivakami

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Experimentally induced diabetes in the rat resulted in an increased level of alpha-glycosidases in the intestine but a depression in their levels in the kidney. Rat intestine exhibited a differential stimulation of maltase, sucrase and trehalase activities. The variations depended on the duration of diabetes and the β-cytotoxic compounds used i.e. alloxan and streptozotocin. The maximum elevation in terms of total units and specific activity was observed on the 30th day in the following order: maltase > sucrase > trehalase. A significant observation emerging from this study is that the level of intestinal enzymes increases while that of the kidney enzymes declined during the period. Although intestinal and renal alpha-glycosidases are known to be structurally and biochemically similar, their opposing responses to diabetes indicates that they are under different regulatory mechanisms in these tissues.

Original languageEnglish (US)
Pages (from-to)647-656
Number of pages10
JournalBiochemistry and Molecular Biology International
Volume44
Issue number4
DOIs
StatePublished - Apr 1998

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

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