Responses to mild cold stress are predicted by different individual characteristics in young and older subjects

David W. DeGroot, George Havenith, W. Larry Kenney

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Older individuals' ability to maintain core temperature during cold stress is impaired; however, the relative importance of individual characteristics that influence this response are unknown. The purpose of this study was to determine the relative influence of individual characteristics on core temperature and tissue insulation (It) during mild cold stress. Forty-two young (23 ± 1 yr, range 18-30 yr) and 46 older (71 ± 1 yr, range 65-89 yr) subjects, varying widely in muscularity, adiposity, and body size, underwent a transient cooling protocol during which esophageal temperature (Tes) was measured continuously and It was calculated using standard equations. Multiple-regression analyses were performed to determine predictors of Tes and It, and standardized regression coefficients were analyzed to determine the relative influence of each predictor. Candidate predictors included age, sex, weight, body surface area, body surface area-to-mass ratio, sum of skinfolds, percent fat, appendicular skeletal muscle mass, and thyroid hormone concentrations (triiodothyronine, thyronine). The sum of skinfolds explained 67% (P < 0.01) of the Tes variance in young subjects vs. 2% (P = 0.30) in older subjects. Conversely, appendicular skeletal muscle mass explained a greater portion of the variance in older subjects for both Tes (older: 28%, P < 0.01; young: 8%, not significant) and It (older: 46%, P < 0.01; young: 17%, P < 0.01). The T es residual variance was considerably larger in older subjects (59-72% vs. 14-42% in young subjects), possibly due to varying rates of physiological aging. These results suggest that the relative influence of individual characteristics changes with aging.

Original languageEnglish (US)
Pages (from-to)1607-1615
Number of pages9
JournalJournal of applied physiology
Volume101
Issue number6
DOIs
StatePublished - Dec 1 2006

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this