Resting network plasticity following brain injury

Toru Nakamura, Frank Gerard Hillary, Bharat B. Biswal

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

The purpose of this study was to examine neural network properties at separate time-points during recovery from traumatic brain injury (TBI) using graph theory. Whole-brain analyses of the topological properties of the fMRI signal were conducted in 6 participants at 3 months and 6 months following severe TBI. Results revealed alterations of network properties including a change in the degree distribution, reduced overall strength in connectivity, and increased ''small-worldness'' from 3 months to 6 months post injury. The findings here indicate that, during recovery from injury, the strength but not the number of network connections diminishes, so that over the course of recovery, the network begins to approximate what is observed in healthy adults. These are the first data examining functional connectivity in a disrupted neural system during recovery.

Original languageEnglish (US)
Article numbere8220
JournalPloS one
Volume4
Issue number12
DOIs
StatePublished - Dec 1 2009

Fingerprint

Brain Injuries
Plasticity
Brain
brain
Recovery
Wounds and Injuries
Magnetic Resonance Imaging
neural networks
Graph theory
Neural networks
Traumatic Brain Injury

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Nakamura, Toru ; Hillary, Frank Gerard ; Biswal, Bharat B. / Resting network plasticity following brain injury. In: PloS one. 2009 ; Vol. 4, No. 12.
@article{4ccd6382168841289c68a6ccc4837422,
title = "Resting network plasticity following brain injury",
abstract = "The purpose of this study was to examine neural network properties at separate time-points during recovery from traumatic brain injury (TBI) using graph theory. Whole-brain analyses of the topological properties of the fMRI signal were conducted in 6 participants at 3 months and 6 months following severe TBI. Results revealed alterations of network properties including a change in the degree distribution, reduced overall strength in connectivity, and increased ''small-worldness'' from 3 months to 6 months post injury. The findings here indicate that, during recovery from injury, the strength but not the number of network connections diminishes, so that over the course of recovery, the network begins to approximate what is observed in healthy adults. These are the first data examining functional connectivity in a disrupted neural system during recovery.",
author = "Toru Nakamura and Hillary, {Frank Gerard} and Biswal, {Bharat B.}",
year = "2009",
month = "12",
day = "1",
doi = "10.1371/journal.pone.0008220",
language = "English (US)",
volume = "4",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

Resting network plasticity following brain injury. / Nakamura, Toru; Hillary, Frank Gerard; Biswal, Bharat B.

In: PloS one, Vol. 4, No. 12, e8220, 01.12.2009.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Resting network plasticity following brain injury

AU - Nakamura, Toru

AU - Hillary, Frank Gerard

AU - Biswal, Bharat B.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - The purpose of this study was to examine neural network properties at separate time-points during recovery from traumatic brain injury (TBI) using graph theory. Whole-brain analyses of the topological properties of the fMRI signal were conducted in 6 participants at 3 months and 6 months following severe TBI. Results revealed alterations of network properties including a change in the degree distribution, reduced overall strength in connectivity, and increased ''small-worldness'' from 3 months to 6 months post injury. The findings here indicate that, during recovery from injury, the strength but not the number of network connections diminishes, so that over the course of recovery, the network begins to approximate what is observed in healthy adults. These are the first data examining functional connectivity in a disrupted neural system during recovery.

AB - The purpose of this study was to examine neural network properties at separate time-points during recovery from traumatic brain injury (TBI) using graph theory. Whole-brain analyses of the topological properties of the fMRI signal were conducted in 6 participants at 3 months and 6 months following severe TBI. Results revealed alterations of network properties including a change in the degree distribution, reduced overall strength in connectivity, and increased ''small-worldness'' from 3 months to 6 months post injury. The findings here indicate that, during recovery from injury, the strength but not the number of network connections diminishes, so that over the course of recovery, the network begins to approximate what is observed in healthy adults. These are the first data examining functional connectivity in a disrupted neural system during recovery.

UR - http://www.scopus.com/inward/record.url?scp=77954043136&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954043136&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0008220

DO - 10.1371/journal.pone.0008220

M3 - Article

C2 - 20011533

AN - SCOPUS:77954043136

VL - 4

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 12

M1 - e8220

ER -