Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms

J. Ferri, J. M. Ford, B. J. Roach, J. A. Turner, T. G. Van Erp, J. Voyvodic, A. Preda, A. Belger, J. Bustillo, D. O'Leary, B. A. Mueller, K. O. Lim, S. C. McEwen, V. D. Calhoun, Michele Theresa Diaz, G. Glover, D. Greve, C. G. Wible, J. G. Vaidya, S. G. PotkinD. H. Mathalon

Research output: Contribution to journalArticle

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Abstract

Background Schizophrenia (SZ) is a severe neuropsychiatric disorder associated with disrupted connectivity within the thalamic-cortico-cerebellar network. Resting-state functional connectivity studies have reported thalamic hypoconnectivity with the cerebellum and prefrontal cortex as well as thalamic hyperconnectivity with sensory cortical regions in SZ patients compared with healthy comparison participants (HCs). However, fundamental questions remain regarding the clinical significance of these connectivity abnormalities.Method Resting state seed-based functional connectivity was used to investigate thalamus to whole brain connectivity using multi-site data including 183 SZ patients and 178 matched HCs. Statistical significance was based on a voxel-level FWE-corrected height threshold of p < 0.001. The relationships between positive and negative symptoms of SZ and regions of the brain demonstrating group differences in thalamic connectivity were examined.Results HC and SZ participants both demonstrated widespread positive connectivity between the thalamus and cortical regions. Compared with HCs, SZ patients had reduced thalamic connectivity with bilateral cerebellum and anterior cingulate cortex. In contrast, SZ patients had greater thalamic connectivity with multiple sensory-motor regions, including bilateral pre-and post-central gyrus, middle/inferior occipital gyrus, and middle/superior temporal gyrus. Thalamus to middle temporal gyrus connectivity was positively correlated with hallucinations and delusions, while thalamus to cerebellar connectivity was negatively correlated with delusions and bizarre behavior.Conclusions Thalamic hyperconnectivity with sensory regions and hypoconnectivity with cerebellar regions in combination with their relationship to clinical features of SZ suggest that thalamic dysconnectivity may be a core neurobiological feature of SZ that underpins positive symptoms.

Original languageEnglish (US)
Pages (from-to)2492-2499
Number of pages8
JournalPsychological medicine
Volume48
Issue number15
DOIs
StatePublished - Nov 1 2018

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Schizophrenia
Thalamus
Delusions
Temporal Lobe
Cerebellum
Occipital Lobe
Somatosensory Cortex
Hallucinations
Gyrus Cinguli
Brain
Prefrontal Cortex
Seeds
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Ferri, J., Ford, J. M., Roach, B. J., Turner, J. A., Van Erp, T. G., Voyvodic, J., ... Mathalon, D. H. (2018). Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms. Psychological medicine, 48(15), 2492-2499. https://doi.org/10.1017/S003329171800003X
Ferri, J. ; Ford, J. M. ; Roach, B. J. ; Turner, J. A. ; Van Erp, T. G. ; Voyvodic, J. ; Preda, A. ; Belger, A. ; Bustillo, J. ; O'Leary, D. ; Mueller, B. A. ; Lim, K. O. ; McEwen, S. C. ; Calhoun, V. D. ; Diaz, Michele Theresa ; Glover, G. ; Greve, D. ; Wible, C. G. ; Vaidya, J. G. ; Potkin, S. G. ; Mathalon, D. H. / Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms. In: Psychological medicine. 2018 ; Vol. 48, No. 15. pp. 2492-2499.
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abstract = "Background Schizophrenia (SZ) is a severe neuropsychiatric disorder associated with disrupted connectivity within the thalamic-cortico-cerebellar network. Resting-state functional connectivity studies have reported thalamic hypoconnectivity with the cerebellum and prefrontal cortex as well as thalamic hyperconnectivity with sensory cortical regions in SZ patients compared with healthy comparison participants (HCs). However, fundamental questions remain regarding the clinical significance of these connectivity abnormalities.Method Resting state seed-based functional connectivity was used to investigate thalamus to whole brain connectivity using multi-site data including 183 SZ patients and 178 matched HCs. Statistical significance was based on a voxel-level FWE-corrected height threshold of p < 0.001. The relationships between positive and negative symptoms of SZ and regions of the brain demonstrating group differences in thalamic connectivity were examined.Results HC and SZ participants both demonstrated widespread positive connectivity between the thalamus and cortical regions. Compared with HCs, SZ patients had reduced thalamic connectivity with bilateral cerebellum and anterior cingulate cortex. In contrast, SZ patients had greater thalamic connectivity with multiple sensory-motor regions, including bilateral pre-and post-central gyrus, middle/inferior occipital gyrus, and middle/superior temporal gyrus. Thalamus to middle temporal gyrus connectivity was positively correlated with hallucinations and delusions, while thalamus to cerebellar connectivity was negatively correlated with delusions and bizarre behavior.Conclusions Thalamic hyperconnectivity with sensory regions and hypoconnectivity with cerebellar regions in combination with their relationship to clinical features of SZ suggest that thalamic dysconnectivity may be a core neurobiological feature of SZ that underpins positive symptoms.",
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Ferri, J, Ford, JM, Roach, BJ, Turner, JA, Van Erp, TG, Voyvodic, J, Preda, A, Belger, A, Bustillo, J, O'Leary, D, Mueller, BA, Lim, KO, McEwen, SC, Calhoun, VD, Diaz, MT, Glover, G, Greve, D, Wible, CG, Vaidya, JG, Potkin, SG & Mathalon, DH 2018, 'Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms', Psychological medicine, vol. 48, no. 15, pp. 2492-2499. https://doi.org/10.1017/S003329171800003X

Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms. / Ferri, J.; Ford, J. M.; Roach, B. J.; Turner, J. A.; Van Erp, T. G.; Voyvodic, J.; Preda, A.; Belger, A.; Bustillo, J.; O'Leary, D.; Mueller, B. A.; Lim, K. O.; McEwen, S. C.; Calhoun, V. D.; Diaz, Michele Theresa; Glover, G.; Greve, D.; Wible, C. G.; Vaidya, J. G.; Potkin, S. G.; Mathalon, D. H.

In: Psychological medicine, Vol. 48, No. 15, 01.11.2018, p. 2492-2499.

Research output: Contribution to journalArticle

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T1 - Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms

AU - Ferri, J.

AU - Ford, J. M.

AU - Roach, B. J.

AU - Turner, J. A.

AU - Van Erp, T. G.

AU - Voyvodic, J.

AU - Preda, A.

AU - Belger, A.

AU - Bustillo, J.

AU - O'Leary, D.

AU - Mueller, B. A.

AU - Lim, K. O.

AU - McEwen, S. C.

AU - Calhoun, V. D.

AU - Diaz, Michele Theresa

AU - Glover, G.

AU - Greve, D.

AU - Wible, C. G.

AU - Vaidya, J. G.

AU - Potkin, S. G.

AU - Mathalon, D. H.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background Schizophrenia (SZ) is a severe neuropsychiatric disorder associated with disrupted connectivity within the thalamic-cortico-cerebellar network. Resting-state functional connectivity studies have reported thalamic hypoconnectivity with the cerebellum and prefrontal cortex as well as thalamic hyperconnectivity with sensory cortical regions in SZ patients compared with healthy comparison participants (HCs). However, fundamental questions remain regarding the clinical significance of these connectivity abnormalities.Method Resting state seed-based functional connectivity was used to investigate thalamus to whole brain connectivity using multi-site data including 183 SZ patients and 178 matched HCs. Statistical significance was based on a voxel-level FWE-corrected height threshold of p < 0.001. The relationships between positive and negative symptoms of SZ and regions of the brain demonstrating group differences in thalamic connectivity were examined.Results HC and SZ participants both demonstrated widespread positive connectivity between the thalamus and cortical regions. Compared with HCs, SZ patients had reduced thalamic connectivity with bilateral cerebellum and anterior cingulate cortex. In contrast, SZ patients had greater thalamic connectivity with multiple sensory-motor regions, including bilateral pre-and post-central gyrus, middle/inferior occipital gyrus, and middle/superior temporal gyrus. Thalamus to middle temporal gyrus connectivity was positively correlated with hallucinations and delusions, while thalamus to cerebellar connectivity was negatively correlated with delusions and bizarre behavior.Conclusions Thalamic hyperconnectivity with sensory regions and hypoconnectivity with cerebellar regions in combination with their relationship to clinical features of SZ suggest that thalamic dysconnectivity may be a core neurobiological feature of SZ that underpins positive symptoms.

AB - Background Schizophrenia (SZ) is a severe neuropsychiatric disorder associated with disrupted connectivity within the thalamic-cortico-cerebellar network. Resting-state functional connectivity studies have reported thalamic hypoconnectivity with the cerebellum and prefrontal cortex as well as thalamic hyperconnectivity with sensory cortical regions in SZ patients compared with healthy comparison participants (HCs). However, fundamental questions remain regarding the clinical significance of these connectivity abnormalities.Method Resting state seed-based functional connectivity was used to investigate thalamus to whole brain connectivity using multi-site data including 183 SZ patients and 178 matched HCs. Statistical significance was based on a voxel-level FWE-corrected height threshold of p < 0.001. The relationships between positive and negative symptoms of SZ and regions of the brain demonstrating group differences in thalamic connectivity were examined.Results HC and SZ participants both demonstrated widespread positive connectivity between the thalamus and cortical regions. Compared with HCs, SZ patients had reduced thalamic connectivity with bilateral cerebellum and anterior cingulate cortex. In contrast, SZ patients had greater thalamic connectivity with multiple sensory-motor regions, including bilateral pre-and post-central gyrus, middle/inferior occipital gyrus, and middle/superior temporal gyrus. Thalamus to middle temporal gyrus connectivity was positively correlated with hallucinations and delusions, while thalamus to cerebellar connectivity was negatively correlated with delusions and bizarre behavior.Conclusions Thalamic hyperconnectivity with sensory regions and hypoconnectivity with cerebellar regions in combination with their relationship to clinical features of SZ suggest that thalamic dysconnectivity may be a core neurobiological feature of SZ that underpins positive symptoms.

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Ferri J, Ford JM, Roach BJ, Turner JA, Van Erp TG, Voyvodic J et al. Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms. Psychological medicine. 2018 Nov 1;48(15):2492-2499. https://doi.org/10.1017/S003329171800003X