Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations known as dysthesias and an irresistible urge to move the lower limbs. It is a life-long, often progressive condition for which there is currently no cure. RLS is thought to affect approximately 10% of the population. Women are affected twice as often as men, and the prevalence of RLS increases with age. Symptoms usually occur at rest, are worse in the evening, and are relieved by voluntary movement. This article summarizes the diagnostic criteria, genetics, and pathophysiology of RLS, as well as current treatment options and ongoing research on RLS.
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