Restless legs syndrome and perceived olfactory and taste dysfunction: A community-based study

Sheng Zhuang, Xiaodong Yuan, Chaoran Ma, Na Yang, Chun Feng Liu, Muzi Na, John W. Winkelman, Shouling Wu, Xiang Gao

Research output: Contribution to journalArticlepeer-review

Abstract

Background and purpose: Restless legs syndrome (RLS) has been suggested as a prodromal symptom of Parkinson disease (PD). Olfactory or taste dysfunction can also occur preceding PD diagnosis. However, whether RLS is associated with chemosensory dysfunction remains unknown. We thus aim to investigate the association between RLS and perceived olfactory and taste dysfunction. Methods: We performed a cross-sectional analysis including 90,337 Chinese adults free of neurodegenerative diseases in the Kailuan study in 2016. Presence of RLS was defined using revised RLS diagnostic criteria or the Cambridge-Hopkins questionnaire for RLS. Perceived olfactory and taste dysfunction was collected via a questionnaire. The association between RLS and perceived olfactory and taste dysfunction was assessed using logistic regression model, adjusting for potential cofounders such as age, sex, and medical history. Results: RLS was associated with high odds of having perceived olfactory and/or taste dysfunction (adjusted odds ratio = 5.92, 95% confidence interval = 3.11–11.3). The significant association persisted when using the Cambridge-Hopkins questionnaire (adjusted odds ratio = 5.55, 95% confidence interval = 2.37–13.0) or when excluding participants with major chronic diseases. Conclusions: RLS was associated with increased odds of perceived olfactory and taste dysfunction.

Original languageEnglish (US)
Pages (from-to)2688-2693
Number of pages6
JournalEuropean Journal of Neurology
Volume28
Issue number8
DOIs
StatePublished - Aug 2021

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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