Restraint stress-induced suppression of major histocompatibility complex class II expression by murine peritoneal macrophages

Bruce S. Zwilling, Mark Dinkins, Rob Christner, Mary Faris, Ann Griffin, Mary Hilburger, Mary McPeek, Dennis Pearl

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The macrophage plays a central role in the development of immune response. Macrophages take up and process antigen which is presented to antigen-responsive T lymphoctes in assoication with major histocompatibility complex class II (Ia) glycoproteins. We have investigated the effect of restraint stress on Ia expression by murine peritoneal macrophages. Stress resulted in a suppression of Ia expression which coincided with an increase in plasma corticosterone levels. In vitro exprements indicate that suppression of Ia expression can occur within 2 h after exposure to corticosterone. The suppression of this important aspect of macrophage function by stressors has important implications regarding the possible immunosuppressive effects of stress on the response of lymphocytes to antigens that depend on intact macrophage function.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalJournal of Neuroimmunology
Issue number1-3
Publication statusPublished - Jan 1 1990


All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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