Rethinking the extrinsic incubation period of malaria parasites

Johanna R. Ohm, Francesco Baldini, Priscille Barreaux, Thierry Lefevre, Penelope A. Lynch, Eunho Suh, Shelley A. Whitehead, Matthew B. Thomas

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

The time it takes for malaria parasites to develop within a mosquito, and become transmissible, is known as the extrinsic incubation period, or EIP. EIP is a key parameter influencing transmission intensity as it combines with mosquito mortality rate and competence to determine the number of mosquitoes that ultimately become infectious. In spite of its epidemiological significance, data on EIP are scant. Current approaches to estimate EIP are largely based on temperature-dependent models developed from data collected on parasite development within a single mosquito species in the 1930s. These models assume that the only factor affecting EIP is mean environmental temperature. Here, we review evidence to suggest that in addition to mean temperature, EIP is likely influenced by genetic diversity of the vector, diversity of the parasite, and variation in a range of biotic and abiotic factors that affect mosquito condition. We further demonstrate that the classic approach of measuring EIP as the time at which mosquitoes first become infectious likely misrepresents EIP for a mosquito population. We argue for a better understanding of EIP to improve models of transmission, refine predictions of the possible impacts of climate change, and determine the potential evolutionary responses of malaria parasites to current and future mosquito control tools.

Original languageEnglish (US)
Article number178
JournalParasites and Vectors
Volume11
Issue number1
DOIs
StatePublished - Mar 12 2018

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

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    Ohm, J. R., Baldini, F., Barreaux, P., Lefevre, T., Lynch, P. A., Suh, E., Whitehead, S. A., & Thomas, M. B. (2018). Rethinking the extrinsic incubation period of malaria parasites. Parasites and Vectors, 11(1), [178]. https://doi.org/10.1186/s13071-018-2761-4