Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.

Adam Bleier Glick, K. C. Flanders, D. Danielpour, S. H. Yuspa, M. B. Sporn

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Abstract

We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.

Original languageEnglish (US)
Pages (from-to)87-97
Number of pages11
JournalCell regulation
Volume1
Issue number1
StatePublished - Nov 1989

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Glick, A. B., Flanders, K. C., Danielpour, D., Yuspa, S. H., & Sporn, M. B. (1989). Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis. Cell regulation, 1(1), 87-97.