Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.

Adam Bleier Glick, K. C. Flanders, D. Danielpour, S. H. Yuspa, M. B. Sporn

Research output: Contribution to journalArticle

250 Citations (Scopus)

Abstract

We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.

Original languageEnglish (US)
Pages (from-to)87-97
Number of pages11
JournalCell regulation
Volume1
Issue number1
StatePublished - Nov 1989

Fingerprint

Tretinoin
Keratinocytes
Epidermis
Transforming Growth Factor beta
Homeostasis
Maintenance
Pharmacology
Antibodies
DNA

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Glick, A. B., Flanders, K. C., Danielpour, D., Yuspa, S. H., & Sporn, M. B. (1989). Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis. Cell regulation, 1(1), 87-97.
Glick, Adam Bleier ; Flanders, K. C. ; Danielpour, D. ; Yuspa, S. H. ; Sporn, M. B. / Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis. In: Cell regulation. 1989 ; Vol. 1, No. 1. pp. 87-97.
@article{77783dfe64804b7295765b1b7a9989f7,
title = "Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.",
abstract = "We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.",
author = "Glick, {Adam Bleier} and Flanders, {K. C.} and D. Danielpour and Yuspa, {S. H.} and Sporn, {M. B.}",
year = "1989",
month = "11",
language = "English (US)",
volume = "1",
pages = "87--97",
journal = "Molecular Biology of the Cell",
issn = "1059-1524",
publisher = "American Society for Cell Biology",
number = "1",

}

Glick, AB, Flanders, KC, Danielpour, D, Yuspa, SH & Sporn, MB 1989, 'Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.', Cell regulation, vol. 1, no. 1, pp. 87-97.

Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis. / Glick, Adam Bleier; Flanders, K. C.; Danielpour, D.; Yuspa, S. H.; Sporn, M. B.

In: Cell regulation, Vol. 1, No. 1, 11.1989, p. 87-97.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.

AU - Glick, Adam Bleier

AU - Flanders, K. C.

AU - Danielpour, D.

AU - Yuspa, S. H.

AU - Sporn, M. B.

PY - 1989/11

Y1 - 1989/11

N2 - We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.

AB - We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.

UR - http://www.scopus.com/inward/record.url?scp=0024755673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024755673&partnerID=8YFLogxK

M3 - Article

C2 - 2519621

AN - SCOPUS:0024755673

VL - 1

SP - 87

EP - 97

JO - Molecular Biology of the Cell

JF - Molecular Biology of the Cell

SN - 1059-1524

IS - 1

ER -