Understanding the impact of inflammation on retinoid transport and metabolism is important because it has implications for the use of vitamin A in public health, and other retinoids in clinical practice. This chapter focuses on dietary vitamin A and inflammation as modulators of retinoid transport, turnover and catabolism, considering, firstly, the transport of plasma retinol by its transport protein, retinol-binding protein (RBP), and secondly, the expression of several key genes that regulate the storage and oxidation of retinoids. Since reduced plasma retinol concentrations resulting from inflammation can be a "look-alike" for vitamin A deficiency, inflammation is an important and vexing complication for the interpretation of low vitamin A. At the level of regulation of the genes and enzymes that esterify retinol for storage and oxidize it to retinoic acid to maintain healthful retinoid concentrations, inflammation rapidly and acutely down regulates expression of several such genes.
|Original language||English (US)|
|Title of host publication||The Retinoids|
|Subtitle of host publication||Biology, Biochemistry, and Disease|
|Number of pages||16|
|State||Published - Jun 12 2015|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)