Retinoid Turnover and Catabolism: Influences of Diet and Inflammation

A. Catharine Ross, Reza Zolfaghari

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Understanding the impact of inflammation on retinoid transport and metabolism is important because it has implications for the use of vitamin A in public health, and other retinoids in clinical practice. This chapter focuses on dietary vitamin A and inflammation as modulators of retinoid transport, turnover and catabolism, considering, firstly, the transport of plasma retinol by its transport protein, retinol-binding protein (RBP), and secondly, the expression of several key genes that regulate the storage and oxidation of retinoids. Since reduced plasma retinol concentrations resulting from inflammation can be a "look-alike" for vitamin A deficiency, inflammation is an important and vexing complication for the interpretation of low vitamin A. At the level of regulation of the genes and enzymes that esterify retinol for storage and oxidize it to retinoic acid to maintain healthful retinoid concentrations, inflammation rapidly and acutely down regulates expression of several such genes.

Original languageEnglish (US)
Title of host publicationThe Retinoids
Subtitle of host publicationBiology, Biochemistry, and Disease
PublisherWiley-Blackwell
Pages449-464
Number of pages16
ISBN (Electronic)9781118628003
ISBN (Print)9781118627983
DOIs
StatePublished - Jun 12 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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