Retracing enzyme evolution in the (βα)8-barrel scaffold

James D. Stevenson, Stefan Lutz, Stephen Benkovic

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

"Refitting" existing protein scaffolds to generate new enzymes with designed properties is a powerful tool in molecular evolution. Two recently published reports demonstrate the engineering of the ubiquitous (βα)8-Barrel (see picture) scaffold to obtain new enzymatic catalytic properties. These are the first examples of the conversion of the enzyme's activity into that of another by using directed evaluation.

Original languageEnglish (US)
Pages (from-to)1854-1856
Number of pages3
JournalAngewandte Chemie - International Edition
Volume40
Issue number10
DOIs
StatePublished - May 18 2001

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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