"Refitting" existing protein scaffolds to generate new enzymes with designed properties is a powerful tool in molecular evolution. Two recently published reports demonstrate the engineering of the ubiquitous (βα)8-Barrel (see picture) scaffold to obtain new enzymatic catalytic properties. These are the first examples of the conversion of the enzyme's activity into that of another by using directed evaluation.
|Original language||English (US)|
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|State||Published - May 18 2001|
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