Retrospective time-trend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United States

Andreas Sjödin, Richard S. Jones, Jean François Focant, Chester Lapeza, Richard Y. Wang, Ernest E. McGahee, Yalin Zhang, Wayman E. Turner, Bill Slazyk, Larry L. Needham, Donald G. Patterson

Research output: Contribution to journalArticlepeer-review

289 Scopus citations

Abstract

Six polybrominated diphenyl ethers (PBDEs), one hexabromobiphenyl [polybrominated biphenyl (PBB)], and one hexachlorobiphenyl [polychlorinated biphenyl (PCB)] were measured in 40 human serum pools collected in the southeastern United States during 1985 through 2002 and in Seattle, Washington, for 1999 through 2002. The concentrations of most of the PBDEs, which are commercially used as flame retardants in common household and commercial applications, had significant positive correlations with time of sample collection, showing that the concentrations of these compounds are increasing in serum collected in the United States. In contrast, PCB and PBB levels were negatively correlated with sample collection year, indicating that the levels of these compounds have been decreasing since their phaseout in the 1970s.

Original languageEnglish (US)
Pages (from-to)654-658
Number of pages5
JournalEnvironmental health perspectives
Volume112
Issue number6
DOIs
StatePublished - May 2004

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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