Fuzzy extractors (Dodis et al., Eurocrypt 2004) convert repeated noisy readings of a secret into the same uniformly distributed key. To eliminate noise, they require an initial enrollment phase that takes the first noisy reading of the secret and produces a nonsecret helper string to be used in subsequent readings. Reusable fuzzy extractors (Boyen, CCS 2004) remain secure even when this initial enrollment phase is repeated multiple times with noisy versions of the same secret, producing multiple helper strings (for example, when a single person’s biometric is enrolled with multiple unrelated organizations). We construct the first reusable fuzzy extractor that makes no assumptions about how multiple readings of the source are correlated (the only prior construction assumed a very specific, unrealistic class of correlations). The extractor works for binary strings with Hamming noise; it achieves computational security under assumptions on the security of hash functions or in the random oracle model. It is simple and efficient and tolerates near-linear error rates. Our reusable extractor is secure for source distributions of linear min-entropy rate. The construction is also secure for sources with much lower entropy rates—lower than those supported by prior (nonreusable) constructions—assuming that the distribution has some additional structure, namely, that random subsequences of the source have sufficient minentropy. We show that such structural assumptions are necessary to support low entropy rates. We then explore further how different structural properties of a noisy source can be used to construct fuzzy extractors when the error rates are high, building a computationally secure and an information-theoretically secure construction for large-alphabet sources.