Reversal of graft-versus-host disease with infusion of autologous bone marrow

Camillo Ricordi, Anreas G. Tzakis, Adriana Zeevi, Witold B. Rybka, Anthony J. Demetris, Paulo A.C. Fontes, Michael A. Nalesnik, Massimo Trucco, Ferdinand O. Ukah, Edward D. Ball, Edward E. Mullen, Ignazio R. Marino, John J. Fung, Thomas E. Starzl

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80% of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 × 108 and 1.6 × 108 autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalCell Transplantation
Volume3
Issue number2
DOIs
StatePublished - Jan 1 1994

Fingerprint

Graft vs Host Disease
Grafts
Bone
Bone Marrow
Bone Marrow Transplantation
Transplantation Tolerance
Skin
Homologous Transplantation
Immunosuppressive Agents
Bone Marrow Cells
Transplantation (surgical)
Body Weight
Safety
Liver
Cells
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

Cite this

Ricordi, C., Tzakis, A. G., Zeevi, A., Rybka, W. B., Demetris, A. J., Fontes, P. A. C., ... Starzl, T. E. (1994). Reversal of graft-versus-host disease with infusion of autologous bone marrow. Cell Transplantation, 3(2), 187-192. https://doi.org/10.1177/096368979400300207
Ricordi, Camillo ; Tzakis, Anreas G. ; Zeevi, Adriana ; Rybka, Witold B. ; Demetris, Anthony J. ; Fontes, Paulo A.C. ; Nalesnik, Michael A. ; Trucco, Massimo ; Ukah, Ferdinand O. ; Ball, Edward D. ; Mullen, Edward E. ; Marino, Ignazio R. ; Fung, John J. ; Starzl, Thomas E. / Reversal of graft-versus-host disease with infusion of autologous bone marrow. In: Cell Transplantation. 1994 ; Vol. 3, No. 2. pp. 187-192.
@article{7c235f7c2446418a8a69fb3b84d17720,
title = "Reversal of graft-versus-host disease with infusion of autologous bone marrow",
abstract = "Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80{\%} of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 × 108 and 1.6 × 108 autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD.",
author = "Camillo Ricordi and Tzakis, {Anreas G.} and Adriana Zeevi and Rybka, {Witold B.} and Demetris, {Anthony J.} and Fontes, {Paulo A.C.} and Nalesnik, {Michael A.} and Massimo Trucco and Ukah, {Ferdinand O.} and Ball, {Edward D.} and Mullen, {Edward E.} and Marino, {Ignazio R.} and Fung, {John J.} and Starzl, {Thomas E.}",
year = "1994",
month = "1",
day = "1",
doi = "10.1177/096368979400300207",
language = "English (US)",
volume = "3",
pages = "187--192",
journal = "Cell Transplantation",
issn = "0963-6897",
publisher = "Cognizant Communication Corporation",
number = "2",

}

Ricordi, C, Tzakis, AG, Zeevi, A, Rybka, WB, Demetris, AJ, Fontes, PAC, Nalesnik, MA, Trucco, M, Ukah, FO, Ball, ED, Mullen, EE, Marino, IR, Fung, JJ & Starzl, TE 1994, 'Reversal of graft-versus-host disease with infusion of autologous bone marrow', Cell Transplantation, vol. 3, no. 2, pp. 187-192. https://doi.org/10.1177/096368979400300207

Reversal of graft-versus-host disease with infusion of autologous bone marrow. / Ricordi, Camillo; Tzakis, Anreas G.; Zeevi, Adriana; Rybka, Witold B.; Demetris, Anthony J.; Fontes, Paulo A.C.; Nalesnik, Michael A.; Trucco, Massimo; Ukah, Ferdinand O.; Ball, Edward D.; Mullen, Edward E.; Marino, Ignazio R.; Fung, John J.; Starzl, Thomas E.

In: Cell Transplantation, Vol. 3, No. 2, 01.01.1994, p. 187-192.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Reversal of graft-versus-host disease with infusion of autologous bone marrow

AU - Ricordi, Camillo

AU - Tzakis, Anreas G.

AU - Zeevi, Adriana

AU - Rybka, Witold B.

AU - Demetris, Anthony J.

AU - Fontes, Paulo A.C.

AU - Nalesnik, Michael A.

AU - Trucco, Massimo

AU - Ukah, Ferdinand O.

AU - Ball, Edward D.

AU - Mullen, Edward E.

AU - Marino, Ignazio R.

AU - Fung, John J.

AU - Starzl, Thomas E.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80% of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 × 108 and 1.6 × 108 autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD.

AB - Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80% of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 × 108 and 1.6 × 108 autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD.

UR - http://www.scopus.com/inward/record.url?scp=0028324514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028324514&partnerID=8YFLogxK

U2 - 10.1177/096368979400300207

DO - 10.1177/096368979400300207

M3 - Article

C2 - 8012734

AN - SCOPUS:0028324514

VL - 3

SP - 187

EP - 192

JO - Cell Transplantation

JF - Cell Transplantation

SN - 0963-6897

IS - 2

ER -