Reversal of renovascular hypertension by antibodies specific for angiotensin-converting enzyme

R. A. Markle, E. H. Sonnenblick, J. M. Conroy, R. L. Soffer

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Goat antibodies developed against pure rabbit pulmonary angiotensin-converting enzyme (peptidyl dipeptidase, EC 3.4.15.1) were administered intravenously to rats with two-kidney Goldblatt hypertension and to normotensive animals with a sustained, immune-dependent decrease of blood pressure to normal values. A smaller, but also immune-specific, reduction of blood pressure was observed in the normotensive group. The data suggest that heterologous antibody directed against angiotensin-converting enzyme may provide a biologically specific probe for examining the contribution of the renin-angiotensin system to normal and pathologic circulatory states.

Original languageEnglish (US)
Pages (from-to)5702-5705
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume75
Issue number11
DOIs
StatePublished - 1978

All Science Journal Classification (ASJC) codes

  • General

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