Revisiting an old friend: new findings in alphavirus structure and assembly

Julie M. Button, Shefah A. Qazi, Joseph Che Yen Wang, Suchetana Mukhopadhyay

Research output: Contribution to journalReview articlepeer-review

Abstract

Alphaviruses are transmitted by an arthropod vector to a vertebrate host. The disease pathologies, cellular environments, immune responses, and host factors are very different in these organisms. Yet, the virus is able to infect, replicate, and assemble into new particles in these two animals using one set of genetic instructions. The balance between conserved mechanisms and unique strategies during virus assembly is critical for fitness of the virus. In this review, we discuss new findings in receptor binding, polyprotein topology, nucleocapsid core formation, and particle budding that have emerged in the last five years and share opinions on how these new findings might answer some questions regarding alphavirus structure and assembly.

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalCurrent Opinion in Virology
Volume45
DOIs
StatePublished - Dec 2020

All Science Journal Classification (ASJC) codes

  • Virology

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