[Rh(CO)2Cl]2-catalyzed domino reactions involving allylic substitution and subsequent carbocyclization reactions

Brandon L. Ashfeld, Kenneth A. Miller, Anna J. Smith, Kristy Tran, Stephen F. Martin

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

(Chemical Equation Presented) Three novel domino reaction processes have been discovered and developed that employ the regioselective and stereoselective [Rh(CO)2Cl]2-catatyzed alkylations of allylic trifluoroacetates with α-substituted sodiomalonates followed by an intramolecular Pauson-Khand annulation, a [5 + 2] cycloaddition, or a cycloisomerization. A unique aspect of the methodology is that a single catalyst is used to effect sequential transformations simply by increasing the temperature for the second reaction.

Original languageEnglish (US)
Pages (from-to)1661-1663
Number of pages3
JournalOrganic Letters
Volume7
Issue number8
DOIs
StatePublished - Apr 14 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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