(Chemical Equation Presented) Three novel domino reaction processes have been discovered and developed that employ the regioselective and stereoselective [Rh(CO)2Cl]2-catatyzed alkylations of allylic trifluoroacetates with α-substituted sodiomalonates followed by an intramolecular Pauson-Khand annulation, a [5 + 2] cycloaddition, or a cycloisomerization. A unique aspect of the methodology is that a single catalyst is used to effect sequential transformations simply by increasing the temperature for the second reaction.
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry