TY - JOUR
T1 - RHEOLOGICAL BEHAVIOR OF LEUKOCYTES.
AU - Dong, Cheng
AU - Schmid-Schoenbein, Geert W.
AU - Skalak, Richard
PY - 1985/1/1
Y1 - 1985/1/1
N2 - The rheological behavior of white blood cells is important to their passage through the microcirculation and to their egress into surrounding tissue in inflammation or infection. White blood cells exhibit a passive viscoelastic behavior and are also capable of active motion and migration when exposed to a chemotactic agent. In the present paper, a phase of the passive response is treated which simulates the behavior of the cell as a whole, rather than only a small portion. The particular phase modelled here is the recovery of a leukocyte to a spherical shape after deformation to a sausage shape by aspiration into a pipette. After expulsion from the pipette, the cell deformation is recorded on video-tape and the major and minor diameters are measured later. The cells were suspended in a medium that prevented active motion.
AB - The rheological behavior of white blood cells is important to their passage through the microcirculation and to their egress into surrounding tissue in inflammation or infection. White blood cells exhibit a passive viscoelastic behavior and are also capable of active motion and migration when exposed to a chemotactic agent. In the present paper, a phase of the passive response is treated which simulates the behavior of the cell as a whole, rather than only a small portion. The particular phase modelled here is the recovery of a leukocyte to a spherical shape after deformation to a sausage shape by aspiration into a pipette. After expulsion from the pipette, the cell deformation is recorded on video-tape and the major and minor diameters are measured later. The cells were suspended in a medium that prevented active motion.
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M3 - Conference article
AN - SCOPUS:0021862202
VL - 68
SP - 163
EP - 166
JO - American Society of Mechanical Engineers, Applied Mechanics Division, AMD
JF - American Society of Mechanical Engineers, Applied Mechanics Division, AMD
SN - 0160-8835
ER -