The rheological behavior of white blood cells is important to their passage through the microcirculation and to their egress into surrounding tissue in inflammation or infection. White blood cells exhibit a passive viscoelastic behavior and are also capable of active motion and migration when exposed to a chemotactic agent. In the present paper, a phase of the passive response is treated which simulates the behavior of the cell as a whole, rather than only a small portion. The particular phase modelled here is the recovery of a leukocyte to a spherical shape after deformation to a sausage shape by aspiration into a pipette. After expulsion from the pipette, the cell deformation is recorded on video-tape and the major and minor diameters are measured later. The cells were suspended in a medium that prevented active motion.
|Original language||English (US)|
|Number of pages||4|
|Journal||American Society of Mechanical Engineers, Applied Mechanics Division, AMD|
|State||Published - Jan 1 1985|
All Science Journal Classification (ASJC) codes
- Mechanical Engineering