Rheology of sickle cells and its role in microcirculatory dynamics.

S. Chien, A. A. Kaperonis, R. G. King, Herbert Herling Lipowsky, E. A. Schmalzer, L. A. Sung, K. L. Sung, S. Usami

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The alterations in the viscoelastic properties of the hemoglobin S solution following deoxygenation can be correlated, on the one hand, with the gelation of the HbS molecules and, on the other hand, with changes in the rheological behavior of the deoxygenated SS erythrocytes. The abnormal rheology of SS erythrocytes forms the basis of their altered flow behavior through filter pores in vitro and microcirculation in vivo. The results support the notion that the rheological behavior of sickle cells is an important link between the molecular events in hemoglobin S following deoxygenation and the behavior of the cell in the microcirculation. Although recent advances have shed considerable lights on the rheology of sickle cells in a variety of conditions, further studies are needed in order to elucidate the pathophysiological role of cell rheology in this disease, especially in terms of the influence of individual SS cells in the heterogeneous populations and the correlation between in vitro and in vivo behavior of SS cells.

Original languageEnglish (US)
Pages (from-to)151-165
Number of pages15
JournalProgress in clinical and biological research
Volume240
StatePublished - Jan 1 1987

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Rheology
Sickle Hemoglobin
Microcirculation
Erythrocytes
Light
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chien, S., Kaperonis, A. A., King, R. G., Lipowsky, H. H., Schmalzer, E. A., Sung, L. A., ... Usami, S. (1987). Rheology of sickle cells and its role in microcirculatory dynamics. Progress in clinical and biological research, 240, 151-165.
Chien, S. ; Kaperonis, A. A. ; King, R. G. ; Lipowsky, Herbert Herling ; Schmalzer, E. A. ; Sung, L. A. ; Sung, K. L. ; Usami, S. / Rheology of sickle cells and its role in microcirculatory dynamics. In: Progress in clinical and biological research. 1987 ; Vol. 240. pp. 151-165.
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Chien, S, Kaperonis, AA, King, RG, Lipowsky, HH, Schmalzer, EA, Sung, LA, Sung, KL & Usami, S 1987, 'Rheology of sickle cells and its role in microcirculatory dynamics.', Progress in clinical and biological research, vol. 240, pp. 151-165.

Rheology of sickle cells and its role in microcirculatory dynamics. / Chien, S.; Kaperonis, A. A.; King, R. G.; Lipowsky, Herbert Herling; Schmalzer, E. A.; Sung, L. A.; Sung, K. L.; Usami, S.

In: Progress in clinical and biological research, Vol. 240, 01.01.1987, p. 151-165.

Research output: Contribution to journalArticle

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AU - Kaperonis, A. A.

AU - King, R. G.

AU - Lipowsky, Herbert Herling

AU - Schmalzer, E. A.

AU - Sung, L. A.

AU - Sung, K. L.

AU - Usami, S.

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Chien S, Kaperonis AA, King RG, Lipowsky HH, Schmalzer EA, Sung LA et al. Rheology of sickle cells and its role in microcirculatory dynamics. Progress in clinical and biological research. 1987 Jan 1;240:151-165.