Rheology of sodium hyaluronate under physiological conditions

W. E. Krause, E. G. Bellomo, Ralph H. Colby

Research output: Contribution to journalArticlepeer-review

173 Scopus citations

Abstract

Sodium hyaluronate NaHA in phosphate-buffered saline behaves as a typical polyelectrolyte in the high-salt limit, as Newtonian viscosities are observed over a wide range of shear rates. There is no evidence of intermolecule hydrogen bonding causing gel formation in NaHA solutions without protein present. The concentration dependences of viscosity, relaxation time, and terminal modulus are consistent with observations on flexible, neutral polymers in good solvents, which are known to be in the same universality class as flexible polyelectrolytes in the presence of excess salt.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalBiomacromolecules
Volume2
Issue number1
DOIs
StatePublished - Aug 15 2001

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Polymers and Plastics
  • Materials Chemistry

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