Rheopexy of synovial fluid and protein aggregation

Katherine M.N. Oates, Wendy E. Krause, Ronald L. Jones, Ralph H. Colby

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Bovine synovial fluid and albumin solutions of similar concentration are rheopectic (stress increases with time in steady shear). This unusual flow characteristic is caused by protein aggregation, and the total stress is enhanced by entanglement of this tenuous protein network with the long-chain polysaccharide sodium hyaluronate under physiological conditions. Neutron scattering measurements on albumin solutions demonstrate protein aggregation and all measurements are consistent with a weak dipolar attraction energy (of order 3kT) that is most likely augmented by hydrophobic interactions and/or disulfide bond formation between proteins. Protein aggregation appears to play an important role in the mechanical properties of blood and synovial fluid. We also suggest a connection between the observed rheopexy and the remarkable lubrication properties of synovial fluid.

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalJournal of the Royal Society Interface
Volume3
Issue number6
DOIs
StatePublished - Feb 22 2006

Fingerprint

Synovial Fluid
Agglomeration
Proteins
Fluids
Albumins
Lubrication
Neutrons
Hyaluronic Acid
Polysaccharides
Neutron scattering
Hydrophobic and Hydrophilic Interactions
Disulfides
Blood
Sodium
Mechanical properties

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

Cite this

Oates, Katherine M.N. ; Krause, Wendy E. ; Jones, Ronald L. ; Colby, Ralph H. / Rheopexy of synovial fluid and protein aggregation. In: Journal of the Royal Society Interface. 2006 ; Vol. 3, No. 6. pp. 167-174.
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Rheopexy of synovial fluid and protein aggregation. / Oates, Katherine M.N.; Krause, Wendy E.; Jones, Ronald L.; Colby, Ralph H.

In: Journal of the Royal Society Interface, Vol. 3, No. 6, 22.02.2006, p. 167-174.

Research output: Contribution to journalArticle

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