Rifampicin-Carrying Poly(D, L-Lactide) Microspheres: Loading and Release

E. B. Denkbaş, Kaitian Xu, A. Tuncel, E. Plşkin

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Rifampicin-loaded poly(D, L-lactide) (PDLLA) microspheres in the size range of 0.8—8.0//m were prepared by a modified solvent evaporation method. Rifampicin loading was changed by using different types of solvents (i.e. methylene chloride, chloroform, and carbon tetrachloride) with different solvent/polymer ratios and different emulsifiers (i.e. methyl cellulose, gelatin, and Tween-20), and by changing the initial drug/polymer ratio. These rifampicin-loaded PDLLA microspheres degraded much faster in the medium at basic pH (9.8) and at high temperatures (55°C). Rifampicin release was also high under these conditions. It was concluded that rifampicin release was both degradation-and diffusion- controlled.

Original languageEnglish (US)
Pages (from-to)815-825
Number of pages11
JournalJournal of Biomaterials Science, Polymer Edition
Volume6
Issue number9
DOIs
StatePublished - Jan 1 1995

Fingerprint

Rifampin
Microspheres
Carbon tetrachloride
Dichloromethane
Polymers
Chlorine compounds
Cellulose
Evaporation
Methylcellulose
Polysorbates
Carbon Tetrachloride
Methylene Chloride
Degradation
Gelatin
Chloroform
poly(lactide)
Temperature
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Denkbaş, E. B. ; Xu, Kaitian ; Tuncel, A. ; Plşkin, E. / Rifampicin-Carrying Poly(D, L-Lactide) Microspheres : Loading and Release. In: Journal of Biomaterials Science, Polymer Edition. 1995 ; Vol. 6, No. 9. pp. 815-825.
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Rifampicin-Carrying Poly(D, L-Lactide) Microspheres : Loading and Release. / Denkbaş, E. B.; Xu, Kaitian; Tuncel, A.; Plşkin, E.

In: Journal of Biomaterials Science, Polymer Edition, Vol. 6, No. 9, 01.01.1995, p. 815-825.

Research output: Contribution to journalArticle

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T1 - Rifampicin-Carrying Poly(D, L-Lactide) Microspheres

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AU - Xu, Kaitian

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