Rifampicin-Carrying Poly(D, L-Lactide) Microspheres: Loading and Release

E. B. Denkbaş, X. Kaitian, A. Tuncel, E. Plşkin

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Abstract

Rifampicin-loaded poly(D, L-lactide) (PDLLA) microspheres in the size range of 0.8—8.0//m were prepared by a modified solvent evaporation method. Rifampicin loading was changed by using different types of solvents (i.e. methylene chloride, chloroform, and carbon tetrachloride) with different solvent/polymer ratios and different emulsifiers (i.e. methyl cellulose, gelatin, and Tween-20), and by changing the initial drug/polymer ratio. These rifampicin-loaded PDLLA microspheres degraded much faster in the medium at basic pH (9.8) and at high temperatures (55°C). Rifampicin release was also high under these conditions. It was concluded that rifampicin release was both degradation-and diffusion- controlled.

Original languageEnglish (US)
Pages (from-to)815-825
Number of pages11
JournalJournal of Biomaterials Science, Polymer Edition
Volume6
Issue number9
DOIs
Publication statusPublished - Jan 1 1995

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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