Rifampicin carrying polyhydroxybutyrate microspheres as a potential chemoembolization agent

A. Ch Kassab, Kaitian Xu, E. B. Denkbaš, Y. Dou, S. Zhao, E. Piškin

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

In this study, we attempted to prepare microspheres from a microbial biodegradable polyester, i.e. polyhydroxybutyrate (PHB) as a potential chemoembolization agent. The drug loaded PHB microspheres were prepared by a solvent evaporation technique, in which methylene chloride, distilled water, and polyvinyl alcohol were utilized as the solvent, dispersion medium, and emulsifier, respectively. Microspheres were obtained within a size range of 5-100 μm by changing the initial polymer/solvent ratio, emulsifier concentration, stirring rate, and initial drug concentration. It was possible to obtain PHB with very narrow size distributions by applying gravity field-flow fractionation technique. Very high drug loadings of up to 407.6 mg rifampicin/g PHB were achieved. Drug release rates were very rapid. Almost 90% of the drug loaded was released in about 24 h. Both the size and drug content of PHB microspheres were found to be effective in controlling the drug release from these microspheres.

Original languageEnglish (US)
Pages (from-to)947-961
Number of pages15
JournalJournal of Biomaterials Science, Polymer Edition
Volume8
Issue number12
DOIs
StatePublished - Jan 1 1997

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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