TY - JOUR
T1 - Right ventricular apical pacing-induced left ventricular dyssynchrony is associated with a subsequent decline in ejection fraction
AU - Ahmed, Mohamed
AU - Gorcsan, John
AU - Marek, Josef
AU - Ryo, Keiko
AU - Haugaa, Kristina
AU - Ludwig, Daniel R.
AU - Schwartzman, David
N1 - Funding Information:
Dr Schwartzman is a consultant to Atricure, Avery-Dennison, Biosense, Estech, and Medtronic. He performs research funded by Biosense, Boston Scientific, and Medtronic. Dr Gorcsan receives research grant support from Biotronik, General Electric Healthcare, Toshiba, Medtronic, and St Jude Medical.
Funding Information:
This research was supported by Medtronic and Boston Scientific. Dr Ahmed is the recipient of the Career Development Award (award no. PR008040244) from the American Society of Echocardiography.
PY - 2014/4
Y1 - 2014/4
N2 - Background: In patients with normal left ventricular (LV) ejection fraction (EF), the interposition of chronic, high-dose right ventricular apical (RVA) pacing may produce late EF decline. Objective: To test the hypothesis that LV dyssynchrony, defined echocardiographically and apparent early after interposition of pacing, would be greater in patients who subsequently demonstrated EF decline. Methods: Ninety-one patients with normal prepacing EF who underwent atrioventricular node ablation and subsequent high-dose RVA pacing were studied. Transthoracic echocardiograms were performed early (median 4 months) and late (median 28 months) after interposition of pacing, with a significant decline in EF between these studies defined as ≥5%. Speckle-tracking longitudinal strain analysis of the early echocardiogram was performed to quantify dyssynchrony. In addition to standard dyssynchrony indices, a novel index of apex-to-base mechanical propagation delay (MPD) was used. Results: Multivariable analysis determined that MPD of the septum correlated with a significant decline in EF, independent of all other dyssynchrony, clinical, or pacing variables. A septal MPD value exceeding 50 ms was associated with EF decline at 81% sensitivity and 88% specificity. Conclusions: Dyssynchrony, in particular septal MPD, measured early after interposition of high-dose RVA pacing predicted a significant late decline in EF in patients who had normal prepacing EF.
AB - Background: In patients with normal left ventricular (LV) ejection fraction (EF), the interposition of chronic, high-dose right ventricular apical (RVA) pacing may produce late EF decline. Objective: To test the hypothesis that LV dyssynchrony, defined echocardiographically and apparent early after interposition of pacing, would be greater in patients who subsequently demonstrated EF decline. Methods: Ninety-one patients with normal prepacing EF who underwent atrioventricular node ablation and subsequent high-dose RVA pacing were studied. Transthoracic echocardiograms were performed early (median 4 months) and late (median 28 months) after interposition of pacing, with a significant decline in EF between these studies defined as ≥5%. Speckle-tracking longitudinal strain analysis of the early echocardiogram was performed to quantify dyssynchrony. In addition to standard dyssynchrony indices, a novel index of apex-to-base mechanical propagation delay (MPD) was used. Results: Multivariable analysis determined that MPD of the septum correlated with a significant decline in EF, independent of all other dyssynchrony, clinical, or pacing variables. A septal MPD value exceeding 50 ms was associated with EF decline at 81% sensitivity and 88% specificity. Conclusions: Dyssynchrony, in particular septal MPD, measured early after interposition of high-dose RVA pacing predicted a significant late decline in EF in patients who had normal prepacing EF.
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U2 - 10.1016/j.hrthm.2013.12.020
DO - 10.1016/j.hrthm.2013.12.020
M3 - Article
C2 - 24333287
AN - SCOPUS:84896981944
VL - 11
SP - 602
EP - 608
JO - Heart Rhythm
JF - Heart Rhythm
SN - 1547-5271
IS - 4
ER -