Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles

Martin G. Kociolek; Kyle P. Kalbarczyk

doi:10.1081/SCC-200039452

Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles

Martin G. Kociolek, Kyle P. Kalbarczyk

School of Science (Behrend)

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or para-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditions in good to moderate yields for a variety of substituted 3-bromo-2-isoxazolines.

Original language	English (US)
Pages (from-to)	4387-4394
Number of pages	8
Journal	Synthetic Communications
Volume	34
Issue number	23
DOIs	https://doi.org/10.1081/SCC-200039452
State	Published - Dec 30 2004

All Science Journal Classification (ASJC) codes

Organic Chemistry

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abstract = "3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or para-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditions in good to moderate yields for a variety of substituted 3-bromo-2-isoxazolines.",

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AU - Kalbarczyk, Kyle P.

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Y1 - 2004/12/30

N2 - 3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or para-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditions in good to moderate yields for a variety of substituted 3-bromo-2-isoxazolines.

AB - 3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or para-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditions in good to moderate yields for a variety of substituted 3-bromo-2-isoxazolines.

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M3 - Article

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JO - Synthetic Communications

JF - Synthetic Communications

SN - 0039-7911

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ER -

Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles

Abstract

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