Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles

Martin G. Kociolek, Kyle P. Kalbarczyk

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or para-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditions in good to moderate yields for a variety of substituted 3-bromo-2-isoxazolines.

Original languageEnglish (US)
Pages (from-to)4387-4394
Number of pages8
JournalSynthetic Communications
Volume34
Issue number23
DOIs
StatePublished - Dec 30 2004

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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