Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles

Martin G. Kociolek, Kyle P. Kalbarczyk

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or para-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditions in good to moderate yields for a variety of substituted 3-bromo-2-isoxazolines.

Original languageEnglish (US)
Pages (from-to)4387-4394
Number of pages8
JournalSynthetic Communications
Volume34
Issue number23
DOIs
StatePublished - Dec 30 2004

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Nitriles
Sodium Iodide
4-toluenesulfonic acid
trimethylchlorosilane

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Kociolek, Martin G. ; Kalbarczyk, Kyle P. / Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles. In: Synthetic Communications. 2004 ; Vol. 34, No. 23. pp. 4387-4394.
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Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles. / Kociolek, Martin G.; Kalbarczyk, Kyle P.

In: Synthetic Communications, Vol. 34, No. 23, 30.12.2004, p. 4387-4394.

Research output: Contribution to journalArticle

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