Abstract
3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or para-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditions in good to moderate yields for a variety of substituted 3-bromo-2-isoxazolines.
Original language | English (US) |
---|---|
Pages (from-to) | 4387-4394 |
Number of pages | 8 |
Journal | Synthetic Communications |
Volume | 34 |
Issue number | 23 |
DOIs | |
State | Published - Dec 30 2004 |
All Science Journal Classification (ASJC) codes
- Organic Chemistry