Risk factors for epithelial ovarian carcinoma in India: A case control study in low-incidence population

S. Shanmughapriya, G. Senthilkumar, S. Arun, B. C. Das, K. Natarajaseenivasan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A case-control study to identify the risk factors for ovarian carcinoma in Tiruchirapalli district, Tamilnadu, India a low incidence population was conducted. The invasive epithelial ovarian cancer case patients were 37. The control group consisted of 74 healthy women, matched according to age categories. Subjects were interviewed in person regarding socio demographic and reproductive characteristics. The unconditional logistic regression was performed and tests of statistical significance were based on difference in the log likelihoods and all p values were 2-sided. In logistic regression analysis, the risk of ovarian cancer was strongly related to the increased physical activity (OR: 3.227, 95% CI: 1.143, 9.108), intake of high fat (OR: 6.286, 95% CI: 0.779, 50.701) early age at menarche (OR: 6.389, 95% CI: 2.143, 19.047), post menopausal status (OR: 3.22, 95% CI: 1.417, 7.316). The use of contraceptive methods, tubal ligation, one birth, late menarche was found to be inversely associated with ovarian cancer risk. The risk of ovarian cancer decreased 80% by one birth event, 40% by use of contraceptives and tubal ligation and six times reduced risk for menarche at later age. The present study thus clearly typified this neoplasm as hormone dependent and it is possible to establish that “ovulation” mechanism determine the level of risk for ovarian cancer in this study population. In addition, the difference in the distribution of histologic subtypes in this population compared with high-incidence populations may point to further differences in risk factors.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalInternational Journal of Cancer Research
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Case-Control Studies
India
Ovarian Neoplasms
Menarche
Carcinoma
Incidence
Tubal Sterilization
Population
Hormone-Dependent Neoplasms
Logistic Models
Parturition
Contraceptive Agents
Ovulation
Contraception
Fats
Regression Analysis
Demography
Exercise
Control Groups

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Shanmughapriya, S. ; Senthilkumar, G. ; Arun, S. ; Das, B. C. ; Natarajaseenivasan, K. / Risk factors for epithelial ovarian carcinoma in India : A case control study in low-incidence population. In: International Journal of Cancer Research. 2016 ; Vol. 12, No. 1. pp. 61-68.
@article{04decf7aaa3c47a9ae7cfe5e70b973ac,
title = "Risk factors for epithelial ovarian carcinoma in India: A case control study in low-incidence population",
abstract = "A case-control study to identify the risk factors for ovarian carcinoma in Tiruchirapalli district, Tamilnadu, India a low incidence population was conducted. The invasive epithelial ovarian cancer case patients were 37. The control group consisted of 74 healthy women, matched according to age categories. Subjects were interviewed in person regarding socio demographic and reproductive characteristics. The unconditional logistic regression was performed and tests of statistical significance were based on difference in the log likelihoods and all p values were 2-sided. In logistic regression analysis, the risk of ovarian cancer was strongly related to the increased physical activity (OR: 3.227, 95{\%} CI: 1.143, 9.108), intake of high fat (OR: 6.286, 95{\%} CI: 0.779, 50.701) early age at menarche (OR: 6.389, 95{\%} CI: 2.143, 19.047), post menopausal status (OR: 3.22, 95{\%} CI: 1.417, 7.316). The use of contraceptive methods, tubal ligation, one birth, late menarche was found to be inversely associated with ovarian cancer risk. The risk of ovarian cancer decreased 80{\%} by one birth event, 40{\%} by use of contraceptives and tubal ligation and six times reduced risk for menarche at later age. The present study thus clearly typified this neoplasm as hormone dependent and it is possible to establish that “ovulation” mechanism determine the level of risk for ovarian cancer in this study population. In addition, the difference in the distribution of histologic subtypes in this population compared with high-incidence populations may point to further differences in risk factors.",
author = "S. Shanmughapriya and G. Senthilkumar and S. Arun and Das, {B. C.} and K. Natarajaseenivasan",
year = "2016",
month = "1",
day = "1",
doi = "10.3923/ijcr.2016.61.68",
language = "English (US)",
volume = "12",
pages = "61--68",
journal = "International Journal of Cancer Research",
issn = "1811-9727",
publisher = "Asian Network for Scientific Information",
number = "1",

}

Risk factors for epithelial ovarian carcinoma in India : A case control study in low-incidence population. / Shanmughapriya, S.; Senthilkumar, G.; Arun, S.; Das, B. C.; Natarajaseenivasan, K.

In: International Journal of Cancer Research, Vol. 12, No. 1, 01.01.2016, p. 61-68.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk factors for epithelial ovarian carcinoma in India

T2 - A case control study in low-incidence population

AU - Shanmughapriya, S.

AU - Senthilkumar, G.

AU - Arun, S.

AU - Das, B. C.

AU - Natarajaseenivasan, K.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - A case-control study to identify the risk factors for ovarian carcinoma in Tiruchirapalli district, Tamilnadu, India a low incidence population was conducted. The invasive epithelial ovarian cancer case patients were 37. The control group consisted of 74 healthy women, matched according to age categories. Subjects were interviewed in person regarding socio demographic and reproductive characteristics. The unconditional logistic regression was performed and tests of statistical significance were based on difference in the log likelihoods and all p values were 2-sided. In logistic regression analysis, the risk of ovarian cancer was strongly related to the increased physical activity (OR: 3.227, 95% CI: 1.143, 9.108), intake of high fat (OR: 6.286, 95% CI: 0.779, 50.701) early age at menarche (OR: 6.389, 95% CI: 2.143, 19.047), post menopausal status (OR: 3.22, 95% CI: 1.417, 7.316). The use of contraceptive methods, tubal ligation, one birth, late menarche was found to be inversely associated with ovarian cancer risk. The risk of ovarian cancer decreased 80% by one birth event, 40% by use of contraceptives and tubal ligation and six times reduced risk for menarche at later age. The present study thus clearly typified this neoplasm as hormone dependent and it is possible to establish that “ovulation” mechanism determine the level of risk for ovarian cancer in this study population. In addition, the difference in the distribution of histologic subtypes in this population compared with high-incidence populations may point to further differences in risk factors.

AB - A case-control study to identify the risk factors for ovarian carcinoma in Tiruchirapalli district, Tamilnadu, India a low incidence population was conducted. The invasive epithelial ovarian cancer case patients were 37. The control group consisted of 74 healthy women, matched according to age categories. Subjects were interviewed in person regarding socio demographic and reproductive characteristics. The unconditional logistic regression was performed and tests of statistical significance were based on difference in the log likelihoods and all p values were 2-sided. In logistic regression analysis, the risk of ovarian cancer was strongly related to the increased physical activity (OR: 3.227, 95% CI: 1.143, 9.108), intake of high fat (OR: 6.286, 95% CI: 0.779, 50.701) early age at menarche (OR: 6.389, 95% CI: 2.143, 19.047), post menopausal status (OR: 3.22, 95% CI: 1.417, 7.316). The use of contraceptive methods, tubal ligation, one birth, late menarche was found to be inversely associated with ovarian cancer risk. The risk of ovarian cancer decreased 80% by one birth event, 40% by use of contraceptives and tubal ligation and six times reduced risk for menarche at later age. The present study thus clearly typified this neoplasm as hormone dependent and it is possible to establish that “ovulation” mechanism determine the level of risk for ovarian cancer in this study population. In addition, the difference in the distribution of histologic subtypes in this population compared with high-incidence populations may point to further differences in risk factors.

UR - http://www.scopus.com/inward/record.url?scp=84948159347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948159347&partnerID=8YFLogxK

U2 - 10.3923/ijcr.2016.61.68

DO - 10.3923/ijcr.2016.61.68

M3 - Article

AN - SCOPUS:84948159347

VL - 12

SP - 61

EP - 68

JO - International Journal of Cancer Research

JF - International Journal of Cancer Research

SN - 1811-9727

IS - 1

ER -