RISK OF AIDS AFTER HERPES ZOSTER

Mads Melbye, Tames T. Goedert, Ronald J. Grossman, M. Elaine Eyster, Robert J. Biggar

    Research output: Contribution to journalArticle

    135 Citations (Scopus)

    Abstract

    In a closed internal medicine practice for homosexual men in Central Manhattan herpes zoster developed in 112 men between 1980 and mid-1986. In these patients the incidence of acquired immunodeficiency syndrome (AIDS) was high: Kaplan-Meier survival analysis indicated cumulative incidences of AIDS of 22·8% within 2 years after herpes zoster, 45·5% within 4 years, and an estimated 72·8% after 6 years. Severity of zoster (relative risk, RR=4·6), degree of pain (RR = 3·4), and zoster of the cranial or cervical dermatomes (RR = 2·2) were all associated with a poor outcome. Oral thrush, oral hairy leucoplakia, amoebiasis, and superficial (tinea) fungal infections also indicated an increased risk of AIDS among zoster patients. Oral thrush and oral hairy leucoplakia manifestations were diagnosed an average of 1·2 and 1·1 years, respectively, after the diagnosis of herpes zoster; thus zoster is an early indicator of an impaired immunity. Herpes zoster can be used as a predictor of AIDS and in AIDS risk groups should be regarded as a poor prognostic sign.

    Original languageEnglish (US)
    Pages (from-to)728-731
    Number of pages4
    JournalThe Lancet
    Volume329
    Issue number8535
    DOIs
    StatePublished - Mar 28 1987

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    Herpes Zoster
    Acquired Immunodeficiency Syndrome
    Hairy Leukoplakia
    Oral Candidiasis
    Amebiasis
    Tinea
    Mycoses
    Incidence
    Kaplan-Meier Estimate
    Survival Analysis
    Internal Medicine
    Immunity
    Pain

    All Science Journal Classification (ASJC) codes

    • Medicine(all)

    Cite this

    Melbye, M., Goedert, T. T., Grossman, R. J., Eyster, M. E., & Biggar, R. J. (1987). RISK OF AIDS AFTER HERPES ZOSTER. The Lancet, 329(8535), 728-731. https://doi.org/10.1016/S0140-6736(87)90365-5
    Melbye, Mads ; Goedert, Tames T. ; Grossman, Ronald J. ; Eyster, M. Elaine ; Biggar, Robert J. / RISK OF AIDS AFTER HERPES ZOSTER. In: The Lancet. 1987 ; Vol. 329, No. 8535. pp. 728-731.
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    Melbye, M, Goedert, TT, Grossman, RJ, Eyster, ME & Biggar, RJ 1987, 'RISK OF AIDS AFTER HERPES ZOSTER', The Lancet, vol. 329, no. 8535, pp. 728-731. https://doi.org/10.1016/S0140-6736(87)90365-5

    RISK OF AIDS AFTER HERPES ZOSTER. / Melbye, Mads; Goedert, Tames T.; Grossman, Ronald J.; Eyster, M. Elaine; Biggar, Robert J.

    In: The Lancet, Vol. 329, No. 8535, 28.03.1987, p. 728-731.

    Research output: Contribution to journalArticle

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    Melbye M, Goedert TT, Grossman RJ, Eyster ME, Biggar RJ. RISK OF AIDS AFTER HERPES ZOSTER. The Lancet. 1987 Mar 28;329(8535):728-731. https://doi.org/10.1016/S0140-6736(87)90365-5