Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs

Joshua Muscat, Shu Quan Chen, John Richie, Nasser K. Altorki, Marc Citron, Sara Olson, Alfred I. Neugut, Steven D. Stellman

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

BACKGROUND. Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the development of lung tumors in experimental animals. To the authors' knowledge there are little data regarding whether regular use of NSAIDs reduces the risk of developing lung carcinoma in humans. METHODS. The association between lung carcinoma risk and regular use of NSAIDs, including aspirin, was evaluated in a hospital-based case-control study of 1038 patients and 1002 controls. RESULTS. The relative risk estimate of lung carcinoma associated with using NSAIDs 3 times a week or more for 1 or more years demonstrated an odds ratio (OR) of 0.68 (95% confidence interval [95% CI], 0.53-0.89). Results were similar when separated by lung histologic type. The association varied by smoking status. The OR was 1.28 (95% CI, 0.73-2.25) in never-smokers and 0.60 (95% CI 0.45-0.80) in ever-smokers. The smoking-specific risk estimates for aspirin were similar to those for all NSAIDs. CONCLUSIONS. The results of the current study suggest a possible chemoprotective benefit with the use of NSAIDs among individuals who are former or current smokers.

Original languageEnglish (US)
Pages (from-to)1732-1736
Number of pages5
JournalCancer
Volume97
Issue number7
DOIs
StatePublished - Apr 1 2003

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Anti-Inflammatory Agents
Carcinoma
Lung
Pharmaceutical Preparations
Confidence Intervals
Aspirin
Smoking
Odds Ratio
Case-Control Studies
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Muscat, J., Chen, S. Q., Richie, J., Altorki, N. K., Citron, M., Olson, S., ... Stellman, S. D. (2003). Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs. Cancer, 97(7), 1732-1736. https://doi.org/10.1002/cncr.11242
Muscat, Joshua ; Chen, Shu Quan ; Richie, John ; Altorki, Nasser K. ; Citron, Marc ; Olson, Sara ; Neugut, Alfred I. ; Stellman, Steven D. / Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs. In: Cancer. 2003 ; Vol. 97, No. 7. pp. 1732-1736.
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Muscat, J, Chen, SQ, Richie, J, Altorki, NK, Citron, M, Olson, S, Neugut, AI & Stellman, SD 2003, 'Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs', Cancer, vol. 97, no. 7, pp. 1732-1736. https://doi.org/10.1002/cncr.11242

Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs. / Muscat, Joshua; Chen, Shu Quan; Richie, John; Altorki, Nasser K.; Citron, Marc; Olson, Sara; Neugut, Alfred I.; Stellman, Steven D.

In: Cancer, Vol. 97, No. 7, 01.04.2003, p. 1732-1736.

Research output: Contribution to journalArticle

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T1 - Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs

AU - Muscat, Joshua

AU - Chen, Shu Quan

AU - Richie, John

AU - Altorki, Nasser K.

AU - Citron, Marc

AU - Olson, Sara

AU - Neugut, Alfred I.

AU - Stellman, Steven D.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - BACKGROUND. Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the development of lung tumors in experimental animals. To the authors' knowledge there are little data regarding whether regular use of NSAIDs reduces the risk of developing lung carcinoma in humans. METHODS. The association between lung carcinoma risk and regular use of NSAIDs, including aspirin, was evaluated in a hospital-based case-control study of 1038 patients and 1002 controls. RESULTS. The relative risk estimate of lung carcinoma associated with using NSAIDs 3 times a week or more for 1 or more years demonstrated an odds ratio (OR) of 0.68 (95% confidence interval [95% CI], 0.53-0.89). Results were similar when separated by lung histologic type. The association varied by smoking status. The OR was 1.28 (95% CI, 0.73-2.25) in never-smokers and 0.60 (95% CI 0.45-0.80) in ever-smokers. The smoking-specific risk estimates for aspirin were similar to those for all NSAIDs. CONCLUSIONS. The results of the current study suggest a possible chemoprotective benefit with the use of NSAIDs among individuals who are former or current smokers.

AB - BACKGROUND. Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the development of lung tumors in experimental animals. To the authors' knowledge there are little data regarding whether regular use of NSAIDs reduces the risk of developing lung carcinoma in humans. METHODS. The association between lung carcinoma risk and regular use of NSAIDs, including aspirin, was evaluated in a hospital-based case-control study of 1038 patients and 1002 controls. RESULTS. The relative risk estimate of lung carcinoma associated with using NSAIDs 3 times a week or more for 1 or more years demonstrated an odds ratio (OR) of 0.68 (95% confidence interval [95% CI], 0.53-0.89). Results were similar when separated by lung histologic type. The association varied by smoking status. The OR was 1.28 (95% CI, 0.73-2.25) in never-smokers and 0.60 (95% CI 0.45-0.80) in ever-smokers. The smoking-specific risk estimates for aspirin were similar to those for all NSAIDs. CONCLUSIONS. The results of the current study suggest a possible chemoprotective benefit with the use of NSAIDs among individuals who are former or current smokers.

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