Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs

Joshua E. Muscat, Shu Quan Chen, John P. Richie, Nasser K. Altorki, Marc Citron, Sara Olson, Alfred I. Neugut, Steven D. Stellman

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Abstract

BACKGROUND. Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the development of lung tumors in experimental animals. To the authors' knowledge there are little data regarding whether regular use of NSAIDs reduces the risk of developing lung carcinoma in humans. METHODS. The association between lung carcinoma risk and regular use of NSAIDs, including aspirin, was evaluated in a hospital-based case-control study of 1038 patients and 1002 controls. RESULTS. The relative risk estimate of lung carcinoma associated with using NSAIDs 3 times a week or more for 1 or more years demonstrated an odds ratio (OR) of 0.68 (95% confidence interval [95% CI], 0.53-0.89). Results were similar when separated by lung histologic type. The association varied by smoking status. The OR was 1.28 (95% CI, 0.73-2.25) in never-smokers and 0.60 (95% CI 0.45-0.80) in ever-smokers. The smoking-specific risk estimates for aspirin were similar to those for all NSAIDs. CONCLUSIONS. The results of the current study suggest a possible chemoprotective benefit with the use of NSAIDs among individuals who are former or current smokers.

Original languageEnglish (US)
Pages (from-to)1732-1736
Number of pages5
JournalCancer
Volume97
Issue number7
DOIs
Publication statusPublished - Apr 1 2003

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Muscat, J. E., Chen, S. Q., Richie, J. P., Altorki, N. K., Citron, M., Olson, S., ... Stellman, S. D. (2003). Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs. Cancer, 97(7), 1732-1736. https://doi.org/10.1002/cncr.11242