RNA-guided genome editing à la carte

Philippe Horvath, Rodolphe Barrangou

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Two recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage.

Original languageEnglish (US)
Pages (from-to)733-734
Number of pages2
JournalCell Research
Volume23
Issue number6
DOIs
StatePublished - Jun 2013

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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    Horvath, P., & Barrangou, R. (2013). RNA-guided genome editing à la carte. Cell Research, 23(6), 733-734. https://doi.org/10.1038/cr.2013.39