Abstract
Mg2+ is essential for RNA folding and catalysis. However, for the first 1.5 billion years of life on Earth RNA inhabited an anoxic Earth with abundant and benign Fe2+. We hypothesize that Fe2+ was an RNA cofactor when iron was abundant, and was substantially replaced by Mg 2+ during a period known as the 'great oxidation', brought on by photosynthesis. Here, we demonstrate that reversing this putative metal substitution in an anoxic environment, by removing Mg2+ and replacing it with Fe2+, expands the catalytic repertoire of RNA. Fe 2+ can confer on some RNAs a previously uncharacterized ability to catalyse single-electron transfer. We propose that RNA function, in analogy with protein function, can be understood fully only in the context of association with a range of possible metals. The catalysis of electron transfer, requisite for metabolic activity, may have been attenuated in RNA by photosynthesis and the rise of O2.
Original language | English (US) |
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Pages (from-to) | 525-528 |
Number of pages | 4 |
Journal | Nature Chemistry |
Volume | 5 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 2013 |
All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Chemical Engineering(all)