Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS

Markus Otto, Robert Bowser, Martin Turner, James Berry, Johannes Brettschneider, James Connor, Jlia Costa, Merit Cudkowicz, Jonathan Glass, Olaf Jahn, Stefan Lehnert, Andrea Malaspina, Lucilla Parnetti, Axel Petzold, Pamela Shaw, Alexander Sherman, Petra Steinacker, Sigurd Sßmuth, Charlotte Teunissen, Hayrettin TumaniAnna Wuolikainen, Albert Ludolph

Research output: Contribution to journalReview article

64 Scopus citations

Abstract

Despite major advances in deciphering the neuropathological hallmarks of amyotrophic lateral sclerosis (ALS), validated neurochemical biomarkers for monitoring disease activity, earlier diagnosis, defining prognosis and unlocking key pathophysiological pathways are lacking. Although several candidate biomarkers exist, translation into clinical application is hindered by small sample numbers, especially longitudinal, for independent verification. This review considers the potential routes to the discovery of neurochemical markers in ALS, and provides a consensus statement on standard operating procedures that will facilitate multicenter collaboration, validation and ultimately clinical translation.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalAmyotrophic Lateral Sclerosis
Volume13
Issue number1
DOIs
StatePublished - Jan 2012

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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    Otto, M., Bowser, R., Turner, M., Berry, J., Brettschneider, J., Connor, J., Costa, J., Cudkowicz, M., Glass, J., Jahn, O., Lehnert, S., Malaspina, A., Parnetti, L., Petzold, A., Shaw, P., Sherman, A., Steinacker, P., Sßmuth, S., Teunissen, C., ... Ludolph, A. (2012). Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS. Amyotrophic Lateral Sclerosis, 13(1), 1-10. https://doi.org/10.3109/17482968.2011.627589