Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections

J. C. De Roode, Andrew Fraser Read, B. H.K. Chan, M. J. Mackinnon

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

We studied infection dynamics of Plasmodium chabaudi in mice infected with 3 genetically distinct clones - 1 less virulent than the other 2 - either on their own or in mixtures. During the acute phase of infection, total numbers of asexual parasites in mixed-clone infections were equal to those produced by the 3 clones alone, suggesting strong in-host competition among clones. During the chronic phase of the infection, mixed-clone infections produced more asexual parasites than single-clone infections, suggesting lower levels of competition than during the acute phase, and indicating that a genetically diverse infection is harder to control by the host immune system. Transmission potential over the whole course of infection was lower from mixed-clone infections than from the average of the 3 single-clone infections. These results suggest that in-host competition reduces both growth rate and probability of transmission for individual parasite clones.

Original languageEnglish (US)
Pages (from-to)411-418
Number of pages8
JournalParasitology
Volume127
Issue number5
DOIs
StatePublished - Nov 1 2003

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Plasmodium chabaudi
malaria
Malaria
Rodentia
Parasites
rodents
Clone Cells
clones
parasites
infection
Infection
Coinfection
mixed infection
immune system
Immune System

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Animal Science and Zoology
  • Infectious Diseases

Cite this

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abstract = "We studied infection dynamics of Plasmodium chabaudi in mice infected with 3 genetically distinct clones - 1 less virulent than the other 2 - either on their own or in mixtures. During the acute phase of infection, total numbers of asexual parasites in mixed-clone infections were equal to those produced by the 3 clones alone, suggesting strong in-host competition among clones. During the chronic phase of the infection, mixed-clone infections produced more asexual parasites than single-clone infections, suggesting lower levels of competition than during the acute phase, and indicating that a genetically diverse infection is harder to control by the host immune system. Transmission potential over the whole course of infection was lower from mixed-clone infections than from the average of the 3 single-clone infections. These results suggest that in-host competition reduces both growth rate and probability of transmission for individual parasite clones.",
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Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections. / De Roode, J. C.; Read, Andrew Fraser; Chan, B. H.K.; Mackinnon, M. J.

In: Parasitology, Vol. 127, No. 5, 01.11.2003, p. 411-418.

Research output: Contribution to journalArticle

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