Role for membrane fluidity in the rate sensitivity of shear stress induced endothelial cell map kinase activity

Peter Butler; Julie Yi Shuan Li; Tsui Chun Tsou; Shunichi Usami; Shu Chien

Role for membrane fluidity in the rate sensitivity of shear stress induced endothelial cell map kinase activity

Peter Butler, Julie Yi Shuan Li, Tsui Chun Tsou, Shunichi Usami, Shu Chien

Research output: Contribution to journal › Conference article › peer-review

Abstract

We investigated the effects of rate of application of shear stress on the activation of MAP kinases (ERK and JNK) in cultured bovine aortic endothelial cells (BAECs). A shear stress of 12 dynes/cm2 was applied either as a step function or as a linear ramp, and maintained for 30 minutes. Our results suggest that the cell membrane senses the rate of change of shear stress in part through changes in membrane fluidity, which in turn play a role in the downstream signaling of MAP kinases.

Original language	English (US)
Pages (from-to)	S-67
Journal	Annals of Biomedical Engineering
Volume	28
Issue number	SUPPL. 1
State	Published - 2000
Event	2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA Duration: Oct 12 2000 → Oct 14 2000

All Science Journal Classification (ASJC) codes

Biomedical Engineering

Cite this

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title = "Role for membrane fluidity in the rate sensitivity of shear stress induced endothelial cell map kinase activity",

abstract = "We investigated the effects of rate of application of shear stress on the activation of MAP kinases (ERK and JNK) in cultured bovine aortic endothelial cells (BAECs). A shear stress of 12 dynes/cm2 was applied either as a step function or as a linear ramp, and maintained for 30 minutes. Our results suggest that the cell membrane senses the rate of change of shear stress in part through changes in membrane fluidity, which in turn play a role in the downstream signaling of MAP kinases.",

author = "Peter Butler and Li, {Julie Yi Shuan} and Tsou, {Tsui Chun} and Shunichi Usami and Shu Chien",

year = "2000",

language = "English (US)",

volume = "28",

pages = "S--67",

journal = "Annals of Biomedical Engineering",

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number = "SUPPL. 1",

note = "2000 Annual Fall Meeting of the Biomedical Engineering Society ; Conference date: 12-10-2000 Through 14-10-2000",

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T1 - Role for membrane fluidity in the rate sensitivity of shear stress induced endothelial cell map kinase activity

AU - Butler, Peter

AU - Li, Julie Yi Shuan

AU - Tsou, Tsui Chun

AU - Usami, Shunichi

AU - Chien, Shu

PY - 2000

Y1 - 2000

N2 - We investigated the effects of rate of application of shear stress on the activation of MAP kinases (ERK and JNK) in cultured bovine aortic endothelial cells (BAECs). A shear stress of 12 dynes/cm2 was applied either as a step function or as a linear ramp, and maintained for 30 minutes. Our results suggest that the cell membrane senses the rate of change of shear stress in part through changes in membrane fluidity, which in turn play a role in the downstream signaling of MAP kinases.

AB - We investigated the effects of rate of application of shear stress on the activation of MAP kinases (ERK and JNK) in cultured bovine aortic endothelial cells (BAECs). A shear stress of 12 dynes/cm2 was applied either as a step function or as a linear ramp, and maintained for 30 minutes. Our results suggest that the cell membrane senses the rate of change of shear stress in part through changes in membrane fluidity, which in turn play a role in the downstream signaling of MAP kinases.

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UR - http://www.scopus.com/inward/citedby.url?scp=0034507111&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0034507111

SN - 0090-6964

VL - 28

SP - S-67

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

IS - SUPPL. 1

T2 - 2000 Annual Fall Meeting of the Biomedical Engineering Society

Y2 - 12 October 2000 through 14 October 2000

ER -

Role for membrane fluidity in the rate sensitivity of shear stress induced endothelial cell map kinase activity

Abstract

All Science Journal Classification (ASJC) codes

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