Role for membrane fluidity in the rate sensitivity of shear stress induced endothelial cell map kinase activity

Peter Butler, Julie Yi Shuan Li, Tsui Chun Tsou, Shunichi Usami, Shu Chien

Research output: Contribution to journalConference articlepeer-review

Abstract

We investigated the effects of rate of application of shear stress on the activation of MAP kinases (ERK and JNK) in cultured bovine aortic endothelial cells (BAECs). A shear stress of 12 dynes/cm2 was applied either as a step function or as a linear ramp, and maintained for 30 minutes. Our results suggest that the cell membrane senses the rate of change of shear stress in part through changes in membrane fluidity, which in turn play a role in the downstream signaling of MAP kinases.

Original languageEnglish (US)
Pages (from-to)S-67
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - Dec 1 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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