Role of angiotensin in thirst

Barbara Jean Rolls, R. J. Wood

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Angiotensin is a potent dipsogenic substance and causes elevated water intake in some pathological conditions but as yet no physiological role for angiotensin in normal thirst has been proven. If angiotensin is important in normal drinking, then it should contribute to the drinking which follows water deprivation. The rehydration of bilaterally nephrectomized rats, rats with bilateral ureteric ligation and control rats was compared after 21 hours of water deprivation. The total intake during the 6 hour rehydration was the same in the 3 groups despite the differences in the level of circulating angiotensin. Thus the renal renin-angiotensin system is not essential for deprivation-induced drinking. Another way to test any contribution to drinking by angiotensin is the administration of the competitive angiotensin inhibitor, saralasin acetate. In a control experiment saralasin acetate was found to block the dipsogenic effect of intravenous angiotensin. The infusion of saralasin acetate in a wide range of doses did not, however, affect the drinking following ligation of the inferior vena cava. Thus angiotensin is not essential for drinking following caval ligation. Two possible explanations for these results are that angiotensin is not normally involved in these types of thirst or that there is redundancy in the control of drinking with compensation for blocked mechanisms.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume6
Issue number3
DOIs
StatePublished - Jan 1 1977

Fingerprint

Thirst
Angiotensins
Drinking
Saralasin
Water Deprivation
Ligation
Fluid Therapy
Water
Rats
Rat control
Venae Cavae
Inferior Vena Cava
Renin-Angiotensin System
Renin
Redundancy
Kidney

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Rolls, Barbara Jean ; Wood, R. J. / Role of angiotensin in thirst. In: Pharmacology, Biochemistry and Behavior. 1977 ; Vol. 6, No. 3. pp. 245-250.
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Role of angiotensin in thirst. / Rolls, Barbara Jean; Wood, R. J.

In: Pharmacology, Biochemistry and Behavior, Vol. 6, No. 3, 01.01.1977, p. 245-250.

Research output: Contribution to journalArticle

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