Role of balloon atrial septostomy before early arterial switch repair of transposition of the great arteries

Barry G. Baylen, Marek Grzeszczak, Marie E. Gleason, Stephen Cyran, Howard Weber, John Myers, John Waldhausen

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Preoperative balloon atrial septostomy is the standard therapy for babies with uncomplicated cyanotic dextrotransposition of the great arteries despite the effectiveness of prostaglandin E1 infusion in alleviating systemic hypoxemia and the reported success of arterial switch repair during the 1st weeks after birth. The clinical records and echocardiographic findings of 23 infants (mean birth weight ± SD 3.3 ± 0.5 kg) with uncomplicated transposition of the great arteries were analyzed. Fifteen infants (Group I) did not undergo septostomy, ana 8 (Group II) underwent septostomy. Before prostaglandin infusion, mean arterial oxygen tension (Po2) in Group I (26 mm Hg) did not differ from that in Group II. After prostaglandin infusion, Po2 increased significantly in Group I (43 ± 8 mm Hg, p < 0.001) but not in Group II despite a widely patent ductus and predominant left to right ductal shunt in all. After septostomy, Po2 increased significantly (43 ± 4 mm Hg, p < 0.03), and did not differ from that in Group I. Echocardiographic features generally demonstrated a nonrestrictive foramen ovale in Group I and a restrictive foramen ovale in Group II. The latter was associated with persistent hypoxemia after prostaglandin. Thus, the diameter of the foramen ovale was the primary factor influencing arterial oxygenation during prostaglandin infusion. Babies underwent the arterial switch operation at a mean age of 70 ± 65 h with an overall survival rate of 96%; there was only one postoperative death (Group II). Absence of septostomy had no negative influence on any postoperative variable, including duration of ventilatory and inotropic support, time to discharge, or mortality. Selected infants with a nonrestrictive patent foramen ovale may undergo successful early arterial switch repair of uncomplicated cyanotic transposition of the great arteries without prior balloon atrial septostomy.

Original languageEnglish (US)
Pages (from-to)1025-1031
Number of pages7
JournalJournal of the American College of Cardiology
Volume19
Issue number5
DOIs
StatePublished - Jan 1 1992

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Transposition of Great Vessels
Foramen Ovale
Prostaglandins
Patent Foramen Ovale
Alprostadil
Birth Weight
Arterial Pressure
Survival Rate
Arteries
Parturition
Oxygen
Mortality
Hypoxia
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Role of balloon atrial septostomy before early arterial switch repair of transposition of the great arteries",
abstract = "Preoperative balloon atrial septostomy is the standard therapy for babies with uncomplicated cyanotic dextrotransposition of the great arteries despite the effectiveness of prostaglandin E1 infusion in alleviating systemic hypoxemia and the reported success of arterial switch repair during the 1st weeks after birth. The clinical records and echocardiographic findings of 23 infants (mean birth weight ± SD 3.3 ± 0.5 kg) with uncomplicated transposition of the great arteries were analyzed. Fifteen infants (Group I) did not undergo septostomy, ana 8 (Group II) underwent septostomy. Before prostaglandin infusion, mean arterial oxygen tension (Po2) in Group I (26 mm Hg) did not differ from that in Group II. After prostaglandin infusion, Po2 increased significantly in Group I (43 ± 8 mm Hg, p < 0.001) but not in Group II despite a widely patent ductus and predominant left to right ductal shunt in all. After septostomy, Po2 increased significantly (43 ± 4 mm Hg, p < 0.03), and did not differ from that in Group I. Echocardiographic features generally demonstrated a nonrestrictive foramen ovale in Group I and a restrictive foramen ovale in Group II. The latter was associated with persistent hypoxemia after prostaglandin. Thus, the diameter of the foramen ovale was the primary factor influencing arterial oxygenation during prostaglandin infusion. Babies underwent the arterial switch operation at a mean age of 70 ± 65 h with an overall survival rate of 96{\%}; there was only one postoperative death (Group II). Absence of septostomy had no negative influence on any postoperative variable, including duration of ventilatory and inotropic support, time to discharge, or mortality. Selected infants with a nonrestrictive patent foramen ovale may undergo successful early arterial switch repair of uncomplicated cyanotic transposition of the great arteries without prior balloon atrial septostomy.",
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Role of balloon atrial septostomy before early arterial switch repair of transposition of the great arteries. / Baylen, Barry G.; Grzeszczak, Marek; Gleason, Marie E.; Cyran, Stephen; Weber, Howard; Myers, John; Waldhausen, John.

In: Journal of the American College of Cardiology, Vol. 19, No. 5, 01.01.1992, p. 1025-1031.

Research output: Contribution to journalArticle

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