Role of electrostatic interactions during protein ultrafiltration

Mahsa M. Rohani, Andrew L. Zydney

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

A number of studies over the last decade have clearly demonstrated the importance of electrostatic interactions on the transport of charged proteins through semipermeable ultrafiltration membranes. This paper provides a review of recent developments in this field with a focus on the role of both protein and membrane charge on the rate of protein transport. Experimental results are analyzed using available theoretical models developed from the solution of the Poisson-Boltzmann equation for the partitioning of a charged particle into a charged pore. The potential of exploiting these electrostatic interactions for selective protein separations and for the development of ultrafiltration membranes with enhanced performance characteristics is also examined.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalAdvances in Colloid and Interface Science
Volume160
Issue number1-2
DOIs
StatePublished - Oct 15 2010

All Science Journal Classification (ASJC) codes

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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