TY - JOUR
T1 - Role of estrogen and stress on the brain-gut axis
AU - Jiang, Yanyan
AU - Van Meerveld, Beverley Greenwood
AU - Johnson, Anthony C.
AU - Travagli, R. Alberto
N1 - Funding Information:
This work was supported by National Institute of Health Grants DK-99350 and DK-120170 to R. A. Travagli. G.-Van Meerveld is a Senior Research Career Scientist with the Department of Veterans Affairs (IK6-BX003610 and I01 BX001195). A. C. Johnson is a Career Development Award Fellow with the Department of Veterans Affairs (IK2-BX003630). The material in this review does not represent the views of the US Department of Veterans Affairs or the United States Government.
Funding Information:
This work was supported by National Institute of Health Grants DK-99350 and DK-120170 to Research Career Scientist with the Department of Veterans Affairs (IK6-BX003610 and I01 BX001195). A. C. Johnson is a Career Development Award Fellow with the Department of Veterans Affairs (IK2-BX003630). US Department of Veterans Affairs or the United States Government.
Publisher Copyright:
© 2019 the American Physiological Society.
PY - 2019/8
Y1 - 2019/8
N2 - Symptoms of functional gastrointestinal disorders (FGIDs), including fullness, bloating, abdominal pain, and altered gastrointestinal (GI) motility, present a significant clinical problem, with a reported prevalence of 25%-40% within the general population. More than 60% of those affected seek and require healthcare, and affected individuals report a significantly decreased quality of life. FGIDs are highly correlated with episodes of acute and chronic stress and are increased in prevalence and reported severity in women compared with men. Although there is evidence that sex and stress interact to exacerbate FGID symptoms, the physiological mechanisms that mediate these sex-dependent disparities are incompletely understood, although hormonal-related differences in GI motility and visceral sensitivity have been purported to play a significant role in the etiology. In this mini review, we will discuss brain-gut axis control of GI motility and sensitivity, the influence of estrogen on GI motility and sensitivity, and stress modulation of the brain-gut axis.
AB - Symptoms of functional gastrointestinal disorders (FGIDs), including fullness, bloating, abdominal pain, and altered gastrointestinal (GI) motility, present a significant clinical problem, with a reported prevalence of 25%-40% within the general population. More than 60% of those affected seek and require healthcare, and affected individuals report a significantly decreased quality of life. FGIDs are highly correlated with episodes of acute and chronic stress and are increased in prevalence and reported severity in women compared with men. Although there is evidence that sex and stress interact to exacerbate FGID symptoms, the physiological mechanisms that mediate these sex-dependent disparities are incompletely understood, although hormonal-related differences in GI motility and visceral sensitivity have been purported to play a significant role in the etiology. In this mini review, we will discuss brain-gut axis control of GI motility and sensitivity, the influence of estrogen on GI motility and sensitivity, and stress modulation of the brain-gut axis.
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U2 - 10.1152/ajpgi.00144.2019
DO - 10.1152/ajpgi.00144.2019
M3 - Review article
C2 - 31241977
AN - SCOPUS:85071348032
VL - 317
SP - G203-G209
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0193-1849
IS - 2
ER -