Role of helix-loop-helix proteins during differentiation of erythroid cells

Archana Anantharaman, I. Ju Lin, Joeva Barrow, Shermi Y. Liang, Jude Masannat, John Strouboulis, Suming Huang, Jörg Bungert

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Helix-loop-helix (HLH) proteins play a profound role in the process of development and cellular differentiation. Among the HLH proteins expressed in differentiating erythroid cells are the ubiquitous proteins Myc, USF1, USF2, and TFII-I, as well as the hematopoiesis-specific transcription factor Tal1/SCL. All of these HLH proteins exhibit distinct functions during the differentiation of erythroid cells. For example, Myc stimulates the proliferation of erythroid progenitor cells, while the USF proteins and Tal1 regulate genes that specify the differentiated phenotype. This minireview summarizes the known activities of Myc, USF, TFII-I, and Tal11/SCL and discusses how they may function sequentially, cooperatively, or antagonistically in regulating expression programs during the differentiation of erythroid cells.

Original languageEnglish (US)
Pages (from-to)1332-1343
Number of pages12
JournalMolecular and cellular biology
Volume31
Issue number7
DOIs
StatePublished - Apr 2011

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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