Role of insular cortex D1 and D2 dopamine receptors in nicotine self-administration in rats

Munir Gunes Kutlu, Dennis Burke, Susan Slade, Brandon J. Hall, Jed E. Rose, Edward D. Levin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The insular cortex has been associated with the processing of rewarding stimuli and with the neural bases of drug addiction. Ischemic damage to the insula has been associated with decreased desire to smoke cigarettes. Which component of insular function is involved in the neural basis of cigarette smoking is not clear. Dopamine systems are crucial for the reinforcing value of addictive drugs. The DA projection from the ventral tegmental area to the nucleus accumbens (NAc) has been shown to be a vital pathway for the primary reinforcement caused by taking a variety of abused drugs. In the current set of studies, the roles of D1 and D2 receptors in the insular cortex in the self-administration of nicotine by rats were assessed. Adult female Sprague-Dawley rats were fitted with jugular catheters and given access to self-administer nicotine. Bilateral local infusion cannulae were implanted into the agranular insular cortex to locally administer D1 and D2 antagonists (SCH-23390 and haloperidol). Acute local infusions of the D1 antagonist SCH-23390 into the insula (1-2μg/side) significantly decreased nicotine self-administration by more than 50%. Repeated infusions of SCH-23390 into the agranular insula caused continuing decreases in nicotine self-administration without signs of tolerance. In contrast, local infusions of the D2 antagonist haloperidol 0.5-2μg/side did not have any discernable effect on nicotine self-administration. These studies show the importance of DA D1 systems in the insula for nicotine reward.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalBehavioural Brain Research
Volume256
DOIs
StatePublished - Nov 1 2013

Fingerprint

Dopamine D1 Receptors
Self Administration
Dopamine D2 Receptors
Nicotine
Cerebral Cortex
Haloperidol
Ventral Tegmental Area
Nucleus Accumbens
Reward
Smoke
Tobacco Products
Pharmaceutical Preparations
Substance-Related Disorders
Sprague Dawley Rats
Dopamine
Neck
Catheters
Smoking
SCH 23390

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Kutlu, Munir Gunes ; Burke, Dennis ; Slade, Susan ; Hall, Brandon J. ; Rose, Jed E. ; Levin, Edward D. / Role of insular cortex D1 and D2 dopamine receptors in nicotine self-administration in rats. In: Behavioural Brain Research. 2013 ; Vol. 256. pp. 273-278.
@article{2dba42804f884dabb2125b7b4f83bd2e,
title = "Role of insular cortex D1 and D2 dopamine receptors in nicotine self-administration in rats",
abstract = "The insular cortex has been associated with the processing of rewarding stimuli and with the neural bases of drug addiction. Ischemic damage to the insula has been associated with decreased desire to smoke cigarettes. Which component of insular function is involved in the neural basis of cigarette smoking is not clear. Dopamine systems are crucial for the reinforcing value of addictive drugs. The DA projection from the ventral tegmental area to the nucleus accumbens (NAc) has been shown to be a vital pathway for the primary reinforcement caused by taking a variety of abused drugs. In the current set of studies, the roles of D1 and D2 receptors in the insular cortex in the self-administration of nicotine by rats were assessed. Adult female Sprague-Dawley rats were fitted with jugular catheters and given access to self-administer nicotine. Bilateral local infusion cannulae were implanted into the agranular insular cortex to locally administer D1 and D2 antagonists (SCH-23390 and haloperidol). Acute local infusions of the D1 antagonist SCH-23390 into the insula (1-2μg/side) significantly decreased nicotine self-administration by more than 50{\%}. Repeated infusions of SCH-23390 into the agranular insula caused continuing decreases in nicotine self-administration without signs of tolerance. In contrast, local infusions of the D2 antagonist haloperidol 0.5-2μg/side did not have any discernable effect on nicotine self-administration. These studies show the importance of DA D1 systems in the insula for nicotine reward.",
author = "Kutlu, {Munir Gunes} and Dennis Burke and Susan Slade and Hall, {Brandon J.} and Rose, {Jed E.} and Levin, {Edward D.}",
year = "2013",
month = "11",
day = "1",
doi = "10.1016/j.bbr.2013.08.005",
language = "English (US)",
volume = "256",
pages = "273--278",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

Role of insular cortex D1 and D2 dopamine receptors in nicotine self-administration in rats. / Kutlu, Munir Gunes; Burke, Dennis; Slade, Susan; Hall, Brandon J.; Rose, Jed E.; Levin, Edward D.

In: Behavioural Brain Research, Vol. 256, 01.11.2013, p. 273-278.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Role of insular cortex D1 and D2 dopamine receptors in nicotine self-administration in rats

AU - Kutlu, Munir Gunes

AU - Burke, Dennis

AU - Slade, Susan

AU - Hall, Brandon J.

AU - Rose, Jed E.

AU - Levin, Edward D.

PY - 2013/11/1

Y1 - 2013/11/1

N2 - The insular cortex has been associated with the processing of rewarding stimuli and with the neural bases of drug addiction. Ischemic damage to the insula has been associated with decreased desire to smoke cigarettes. Which component of insular function is involved in the neural basis of cigarette smoking is not clear. Dopamine systems are crucial for the reinforcing value of addictive drugs. The DA projection from the ventral tegmental area to the nucleus accumbens (NAc) has been shown to be a vital pathway for the primary reinforcement caused by taking a variety of abused drugs. In the current set of studies, the roles of D1 and D2 receptors in the insular cortex in the self-administration of nicotine by rats were assessed. Adult female Sprague-Dawley rats were fitted with jugular catheters and given access to self-administer nicotine. Bilateral local infusion cannulae were implanted into the agranular insular cortex to locally administer D1 and D2 antagonists (SCH-23390 and haloperidol). Acute local infusions of the D1 antagonist SCH-23390 into the insula (1-2μg/side) significantly decreased nicotine self-administration by more than 50%. Repeated infusions of SCH-23390 into the agranular insula caused continuing decreases in nicotine self-administration without signs of tolerance. In contrast, local infusions of the D2 antagonist haloperidol 0.5-2μg/side did not have any discernable effect on nicotine self-administration. These studies show the importance of DA D1 systems in the insula for nicotine reward.

AB - The insular cortex has been associated with the processing of rewarding stimuli and with the neural bases of drug addiction. Ischemic damage to the insula has been associated with decreased desire to smoke cigarettes. Which component of insular function is involved in the neural basis of cigarette smoking is not clear. Dopamine systems are crucial for the reinforcing value of addictive drugs. The DA projection from the ventral tegmental area to the nucleus accumbens (NAc) has been shown to be a vital pathway for the primary reinforcement caused by taking a variety of abused drugs. In the current set of studies, the roles of D1 and D2 receptors in the insular cortex in the self-administration of nicotine by rats were assessed. Adult female Sprague-Dawley rats were fitted with jugular catheters and given access to self-administer nicotine. Bilateral local infusion cannulae were implanted into the agranular insular cortex to locally administer D1 and D2 antagonists (SCH-23390 and haloperidol). Acute local infusions of the D1 antagonist SCH-23390 into the insula (1-2μg/side) significantly decreased nicotine self-administration by more than 50%. Repeated infusions of SCH-23390 into the agranular insula caused continuing decreases in nicotine self-administration without signs of tolerance. In contrast, local infusions of the D2 antagonist haloperidol 0.5-2μg/side did not have any discernable effect on nicotine self-administration. These studies show the importance of DA D1 systems in the insula for nicotine reward.

UR - http://www.scopus.com/inward/record.url?scp=84883695356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883695356&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2013.08.005

DO - 10.1016/j.bbr.2013.08.005

M3 - Article

VL - 256

SP - 273

EP - 278

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -