Role of Precursor mRNA splicing in nutrient-induced alterations in gene expression and metabolism

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Precursor mRNA (pre-mRNA) splicing is a critical step in gene expression that results in the removal of intronic sequences from immature mRNA, leading to the production of mature mRNA that can be translated into protein. Alternative pre-mRNA splicing is the process whereby alternative exons and/or introns are selectively included or excluded, generating mature mRNAs that encode proteins that may differ in function. The resulting alterations in the pattern of protein isoform expression can result in changes in protein-protein interaction, subcellular localization, and flux through metabolic pathways. Although basic mechanisms of pre-mRNA splicing of introns and exons are reasonablywell characterized, how thesemechanisms are regulated remains poorly understood. The goal of this review is to highlight selected recent advances in our understanding of the regulation of pre-mRNA splicing by nutrients and modulation of nutrient metabolism that result from changes in pre-mRNA splicing.

Original languageEnglish (US)
Pages (from-to)841-846
Number of pages6
JournalJournal of Nutrition
Volume145
Issue number5
DOIs
StatePublished - Jan 1 2015

Fingerprint

RNA Precursors
Gene Expression
Food
Introns
Messenger RNA
Exons
Proteins
Metabolic Networks and Pathways
Protein Isoforms

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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abstract = "Precursor mRNA (pre-mRNA) splicing is a critical step in gene expression that results in the removal of intronic sequences from immature mRNA, leading to the production of mature mRNA that can be translated into protein. Alternative pre-mRNA splicing is the process whereby alternative exons and/or introns are selectively included or excluded, generating mature mRNAs that encode proteins that may differ in function. The resulting alterations in the pattern of protein isoform expression can result in changes in protein-protein interaction, subcellular localization, and flux through metabolic pathways. Although basic mechanisms of pre-mRNA splicing of introns and exons are reasonablywell characterized, how thesemechanisms are regulated remains poorly understood. The goal of this review is to highlight selected recent advances in our understanding of the regulation of pre-mRNA splicing by nutrients and modulation of nutrient metabolism that result from changes in pre-mRNA splicing.",
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Role of Precursor mRNA splicing in nutrient-induced alterations in gene expression and metabolism. / Ravi, Suhana; Schilder, Rudolf J.; Kimball, Scot R.

In: Journal of Nutrition, Vol. 145, No. 5, 01.01.2015, p. 841-846.

Research output: Contribution to journalArticle

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