Role of Selenoproteins in Bacterial Pathogenesis

Sarah E. Sumner, Rachel L. Markley, Girish S. Kirimanjeswara

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The trace element selenium is an essential micronutrient that plays an important role in maintaining homeostasis of several tissues including the immune system of mammals. The vast majority of the biological functions of selenium are mediated via selenoproteins, proteins which incorporate the selenium-containing amino acid selenocysteine. Several bacterial infections of humans and animals are associated with decreased levels of selenium in the blood and an adjunct therapy with selenium often leads to favorable outcomes. Many pathogenic bacteria are also capable of synthesizing selenocysteine suggesting that selenoproteins may have a role in bacterial physiology. Interestingly, the composition of host microbiota is also regulated by dietary selenium levels. Therefore, bacterial pathogens, microbiome, and host immune cells may be competing for a limited supply of selenium. Elucidating how selenium, in particular selenoproteins, may regulate pathogen virulence, microbiome diversity, and host immune response during a bacterial infection is critical for clinical management of infectious diseases.

Original languageEnglish (US)
Pages (from-to)69-82
Number of pages14
JournalBiological Trace Element Research
Volume192
Issue number1
DOIs
StatePublished - Nov 1 2019

Fingerprint

Selenoproteins
Selenium
Microbiota
Selenocysteine
Pathogens
Bacterial Infections
Bacterial Physiological Phenomena
Mammals
Micronutrients
Immune system
Physiology
Trace Elements
Communicable Diseases
Virulence
Immune System
Bacteria
Animals
Homeostasis
Blood
Tissue

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry

Cite this

Sumner, Sarah E. ; Markley, Rachel L. ; Kirimanjeswara, Girish S. / Role of Selenoproteins in Bacterial Pathogenesis. In: Biological Trace Element Research. 2019 ; Vol. 192, No. 1. pp. 69-82.
@article{5dc70346911b4d419746925926d8eed5,
title = "Role of Selenoproteins in Bacterial Pathogenesis",
abstract = "The trace element selenium is an essential micronutrient that plays an important role in maintaining homeostasis of several tissues including the immune system of mammals. The vast majority of the biological functions of selenium are mediated via selenoproteins, proteins which incorporate the selenium-containing amino acid selenocysteine. Several bacterial infections of humans and animals are associated with decreased levels of selenium in the blood and an adjunct therapy with selenium often leads to favorable outcomes. Many pathogenic bacteria are also capable of synthesizing selenocysteine suggesting that selenoproteins may have a role in bacterial physiology. Interestingly, the composition of host microbiota is also regulated by dietary selenium levels. Therefore, bacterial pathogens, microbiome, and host immune cells may be competing for a limited supply of selenium. Elucidating how selenium, in particular selenoproteins, may regulate pathogen virulence, microbiome diversity, and host immune response during a bacterial infection is critical for clinical management of infectious diseases.",
author = "Sumner, {Sarah E.} and Markley, {Rachel L.} and Kirimanjeswara, {Girish S.}",
year = "2019",
month = "11",
day = "1",
doi = "10.1007/s12011-019-01877-2",
language = "English (US)",
volume = "192",
pages = "69--82",
journal = "Biological Trace Element Research",
issn = "0163-4984",
publisher = "Humana Press",
number = "1",

}

Role of Selenoproteins in Bacterial Pathogenesis. / Sumner, Sarah E.; Markley, Rachel L.; Kirimanjeswara, Girish S.

In: Biological Trace Element Research, Vol. 192, No. 1, 01.11.2019, p. 69-82.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Role of Selenoproteins in Bacterial Pathogenesis

AU - Sumner, Sarah E.

AU - Markley, Rachel L.

AU - Kirimanjeswara, Girish S.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - The trace element selenium is an essential micronutrient that plays an important role in maintaining homeostasis of several tissues including the immune system of mammals. The vast majority of the biological functions of selenium are mediated via selenoproteins, proteins which incorporate the selenium-containing amino acid selenocysteine. Several bacterial infections of humans and animals are associated with decreased levels of selenium in the blood and an adjunct therapy with selenium often leads to favorable outcomes. Many pathogenic bacteria are also capable of synthesizing selenocysteine suggesting that selenoproteins may have a role in bacterial physiology. Interestingly, the composition of host microbiota is also regulated by dietary selenium levels. Therefore, bacterial pathogens, microbiome, and host immune cells may be competing for a limited supply of selenium. Elucidating how selenium, in particular selenoproteins, may regulate pathogen virulence, microbiome diversity, and host immune response during a bacterial infection is critical for clinical management of infectious diseases.

AB - The trace element selenium is an essential micronutrient that plays an important role in maintaining homeostasis of several tissues including the immune system of mammals. The vast majority of the biological functions of selenium are mediated via selenoproteins, proteins which incorporate the selenium-containing amino acid selenocysteine. Several bacterial infections of humans and animals are associated with decreased levels of selenium in the blood and an adjunct therapy with selenium often leads to favorable outcomes. Many pathogenic bacteria are also capable of synthesizing selenocysteine suggesting that selenoproteins may have a role in bacterial physiology. Interestingly, the composition of host microbiota is also regulated by dietary selenium levels. Therefore, bacterial pathogens, microbiome, and host immune cells may be competing for a limited supply of selenium. Elucidating how selenium, in particular selenoproteins, may regulate pathogen virulence, microbiome diversity, and host immune response during a bacterial infection is critical for clinical management of infectious diseases.

UR - http://www.scopus.com/inward/record.url?scp=85073308656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073308656&partnerID=8YFLogxK

U2 - 10.1007/s12011-019-01877-2

DO - 10.1007/s12011-019-01877-2

M3 - Article

C2 - 31489516

AN - SCOPUS:85073308656

VL - 192

SP - 69

EP - 82

JO - Biological Trace Element Research

JF - Biological Trace Element Research

SN - 0163-4984

IS - 1

ER -