Role of specific microRNAs for endothelial function and angiogenesis

Fusheng Wu, Zeran Yang, Guohong Li

Research output: Contribution to journalShort survey

103 Scopus citations

Abstract

Accumulating evidence indicates that various aspects of angiogenesis, such as proliferation, migration, and morphogenesis of endothelial cells, can be regulated by specific miRNAs in an endothelial-specific manner. As novel molecular targets, miRNAs have a potential value for treatment of angiogenesis-associated diseases such as cancers, inflammation, and vascular diseases. In this article, we review the latest advances in the identification and validation of angiogenesis-regulatory miRNAs and their targets, and discuss their roles and mechanisms in regulating endothelial cell function and angiogenesis.

Original languageEnglish (US)
Pages (from-to)549-553
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume386
Issue number4
DOIs
StatePublished - Sep 4 2009

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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