Role of specific MicroRNAs in regulation of vascular smooth muscle cell differentiation and the response to injury

Zifang Song, Guohong Li

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Vascular smooth muscle cells (VSMCs) exhibit remarkable plasticity during postnatal development. Vascular injury initiates and perpetuates VSMCs dedifferentiation to a synthetic phenotype, which has been increasingly recognized to play a central role in neointimal hyperplasia during the pathogenesis of vascular proliferative diseases. MicroRNAs (miRNAs) are a novel class of regulatory noncoding RNAs that regulate gene expression at the posttranscriptional level by binding to 3′ untranslated regions of target mRNAs, leading to either degrading mRNAs or inhibiting their translation. There is emerging evidence that miRNAs are critical regulators of widespread cellular functions such as differentiation, proliferation, and migration. Recent studies have indicated that a number of specific miRNAs play important roles in regulation of vascular cell functions and contribute to neointimal hyperplasia after vascular injury. Here, we review recent advance regarding functions of specific miRNAs in vasculature and discuss possible mechanisms by which miRNAs modulate proliferation and differentiation of VSMCs.

Original languageEnglish (US)
Pages (from-to)246-250
Number of pages5
JournalJournal of cardiovascular translational research
Volume3
Issue number3
DOIs
StatePublished - Jun 1 2010

Fingerprint

MicroRNAs
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Differentiation
Wounds and Injuries
Vascular System Injuries
Hyperplasia
Cell Dedifferentiation
Untranslated RNA
Messenger RNA
3' Untranslated Regions
Vascular Diseases
Blood Vessels
Phenotype
Gene Expression

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science
  • Medicine(all)

Cite this

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Role of specific MicroRNAs in regulation of vascular smooth muscle cell differentiation and the response to injury. / Song, Zifang; Li, Guohong.

In: Journal of cardiovascular translational research, Vol. 3, No. 3, 01.06.2010, p. 246-250.

Research output: Contribution to journalReview article

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